HLA-A∗03:01 is associated with increased risk of fever, chills, and stronger side effects from Pfizer-BioNTech COVID-19 vaccination
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SciScore for 10.1101/2021.11.16.21266408: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: These are unselected Helix customers and patients in the Renown Health System who chose to consent to participate in research projects and respond to our survey.
IRB: The Helix DNA Discovery Project study was reviewed and approved by Western Institutional Review Board.Sex as a biological variable The participants in this cohort are aged 18 to 89+, 65% are female, and 85% are of European genetic ancestry (Table 1). Randomization not detected. Blinding not detected. Power Analysis not detected. Cell Line Authentication Authentication: This was followed by genotype imputation for all 1000 Genomes Phase 3 sites with MAF>=1% that have genotype quality (GQ) values less than 20. Table 2: Resources
No…
SciScore for 10.1101/2021.11.16.21266408: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: These are unselected Helix customers and patients in the Renown Health System who chose to consent to participate in research projects and respond to our survey.
IRB: The Helix DNA Discovery Project study was reviewed and approved by Western Institutional Review Board.Sex as a biological variable The participants in this cohort are aged 18 to 89+, 65% are female, and 85% are of European genetic ancestry (Table 1). Randomization not detected. Blinding not detected. Power Analysis not detected. Cell Line Authentication Authentication: This was followed by genotype imputation for all 1000 Genomes Phase 3 sites with MAF>=1% that have genotype quality (GQ) values less than 20. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We found bar graphs of continuous data. We recommend replacing bar graphs with more informative graphics, as many different datasets can lead to the same bar graph. The actual data may suggest different conclusions from the summary statistics. For more information, please see Weissgerber et al (2015).
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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