Combinatorial analysis reveals highly coordinated early-stage immune reactions that predict later antiviral immunity in mild COVID-19 patients
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SciScore for 10.1101/2021.08.31.21262713: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: Informed consent was obtained from each participant prior to collection. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis Correlation analysis was based on either Spearman or Pearson correlation as indicated in the corresponding figures. Table 2: Resources
Antibodies Sentences Resources Determination of neutralization antibody capacity by MSD assay: Multiplex assays for the detection of neutralizing antibodies against SARS-CoV-2 (SARS-CoV-2-Spike and SARS-CoV-2 S RBD) were done on patient sera using the MSD COVID-19 ACE2 Neutralization Kits from MSD (Panel 1 reference K15375U) according to the manufacturer’s instructions. SARS-CoV-2sugg…SciScore for 10.1101/2021.08.31.21262713: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: Informed consent was obtained from each participant prior to collection. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis Correlation analysis was based on either Spearman or Pearson correlation as indicated in the corresponding figures. Table 2: Resources
Antibodies Sentences Resources Determination of neutralization antibody capacity by MSD assay: Multiplex assays for the detection of neutralizing antibodies against SARS-CoV-2 (SARS-CoV-2-Spike and SARS-CoV-2 S RBD) were done on patient sera using the MSD COVID-19 ACE2 Neutralization Kits from MSD (Panel 1 reference K15375U) according to the manufacturer’s instructions. SARS-CoV-2suggested: NoneSARS-CoV-2-Spikesuggested: NoneSoftware and Algorithms Sentences Resources The data was analyzed using FlowJo v10.5.6. FlowJosuggested: (FlowJo, RRID:SCR_008520)Statistical analysis: Both PCA and volcano plots were visualized using GraphPad Prism 9.0. GraphPad Prismsuggested: (GraphPad Prism, RRID:SCR_002798)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04380987 Recruiting Luxembourg Cohort of Positive Patients for COVID-19: a Strat… Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: Please consider improving the rainbow (“jet”) colormap(s) used on pages 32, 25 and 34. At least one figure is not accessible to readers with colorblindness and/or is not true to the data, i.e. not perceptually uniform.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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