Bacterial pulmonary superinfections are associated with longer duration of ventilation in critically ill COVID-19 patients
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SciScore for 10.1101/2020.09.10.20191882: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement Consent: Exclusion criteria were patients or relatives denying informed consent and patients still being treated in the ICU when the study period ended.
IRB: Ethics and study registration: The study was approved by the local ethics committee of the Canton of Zurich, Switzerland (Kantonale Ethikkommission Zurich BASEC ID 2020 - 00646).Randomization not detected. Blinding not detected. Power Analysis Statistical analyses: Due to the unknown rate of concomitant infections in severely ill COVID-19 patients a power calculation was not feasible. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Statistical analysis was … SciScore for 10.1101/2020.09.10.20191882: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement Consent: Exclusion criteria were patients or relatives denying informed consent and patients still being treated in the ICU when the study period ended.
IRB: Ethics and study registration: The study was approved by the local ethics committee of the Canton of Zurich, Switzerland (Kantonale Ethikkommission Zurich BASEC ID 2020 - 00646).Randomization not detected. Blinding not detected. Power Analysis Statistical analyses: Due to the unknown rate of concomitant infections in severely ill COVID-19 patients a power calculation was not feasible. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Statistical analysis was performed using STATA version 15 (StataCorp, College Station, TX) STATAsuggested: (Stata, RRID:SCR_012763)StataCorpsuggested: (Stata, RRID:SCR_012763)(SPSS Science, Chicago, IL, USA) and Graphpad Prism 7 (San Diego, CA, USA). SPSSsuggested: (SPSS, RRID:SCR_002865)Graphpad Prismsuggested: (GraphPad Prism, RRID:SCR_002798)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Limitations of the study are the single centre design, small number of patients and the high number of patients with empirical broad-spectrum antibiotic therapy (>90% of cases) at admission. Another limitation is the lack of a uniform internationally valid definition of a bacterial infection of the lower respiratory tract. In summary, the detection of relevant bacterial pulmonary superinfection was associated with a more severe disease course in COVID-19 patients, especially a lower likelihood of ventilator-free survival at 28 days. Future trials should investigate the effect of tailored antimicrobial therapy on outcome, antibiotic resistance and drug use based on longitudinal assessment of respiratory tract cultures.
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04410263 Recruiting Microbiota in COVID-19 Patients for Future Therapeutic and P… Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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