Low awareness of past SARS-CoV-2 infection in healthy plasma donors
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SciScore for 10.1101/2020.08.10.20171561: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement Consent: All participating individuals gave informed consent before participating in the online questionnaire and the study protocol and procedures were approved by Sanquin’s Ethics Advisory Council and its Privacy Officer. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources Individuals that donated plasma anywhere in the Netherlands between May 11th and 18th 2020 who consented (99.7%) to using leftovers of their donation for research were tested for SARS-CoV-2 antibodies. SARS-CoV-2suggested: NoneSoftware and Algorithms Sentences Resources Statistical … SciScore for 10.1101/2020.08.10.20171561: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement Consent: All participating individuals gave informed consent before participating in the online questionnaire and the study protocol and procedures were approved by Sanquin’s Ethics Advisory Council and its Privacy Officer. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources Individuals that donated plasma anywhere in the Netherlands between May 11th and 18th 2020 who consented (99.7%) to using leftovers of their donation for research were tested for SARS-CoV-2 antibodies. SARS-CoV-2suggested: NoneSoftware and Algorithms Sentences Resources Statistical analyses were performed using SPSS, Version 23 (IBM, Armonk, U.S.A.). SPSSsuggested: (SPSS, RRID:SCR_002865)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our study also has limitations. First, study participants were required to be in good health in order to qualify for plasma donation. This selection bias may have resulted in an underrepresentation of SARS-CoV-2 antibody positive individuals and of more severe COVID-19 cases in particular. Second, we asked participating individuals to report their symptoms over a period of almost three months, which obviously introduces a risk of recall bias. Nonetheless, given the unprecedented impact of SARS-CoV-2 on society and the repeated governmental calls to self-isolate with symptoms, we expect that most individuals have an exceptional recollection of their COVID-19 suspicion and symptoms during this period. As governments slowly ease virus control measures, it becomes vital to identify and isolate infected individuals to prevent new SARS-CoV-2 outbreaks.19,20 The presence of anosmia/dysgeusia, especially, should trigger PCR testing.17 In addition, our study confirms the existence of asymptomatic SARS-CoV-2 infections and adds that even symptomatic individuals did not suspect a SARS-CoV-2 infection. Despite the limitations of studies thus far, sufficient evidence of asymptomatic and pre-symptomatic transmission of SARS-CoV-2 exists.16,21 Efforts to identify cases that rely on symptoms may therefore be insufficient, which emphasizes the importance of thorough contact tracing.22 In conclusion, almost half of the individuals that tested positive for antibodies to SARS-CoV-2 in a reliable...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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SciScore for 10.1101/2020.08.10.20171561: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement All participating individuals gave informed consent before participating in the online questionnaire and the study protocol and procedures were approved by Sanquin’s Ethics Advisory Council and its Privacy Officer. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources Only one individual positive for SARSCoV-2 antibodies was admitted to a hospital, but this was because of gastrointestinal complaints. SARSCoV-2suggested: NoneSoftware and … SciScore for 10.1101/2020.08.10.20171561: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement All participating individuals gave informed consent before participating in the online questionnaire and the study protocol and procedures were approved by Sanquin’s Ethics Advisory Council and its Privacy Officer. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources Only one individual positive for SARSCoV-2 antibodies was admitted to a hospital, but this was because of gastrointestinal complaints. SARSCoV-2suggested: NoneSoftware and Algorithms Sentences Resources Statistical analyses were performed using SPSS, Version 23 (IBM, Armonk, U.S.A.). SPSSsuggested: (SPSS, RRID:SCR_002865)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
Our study also has limitations. First, study participants were required to be in good health in order to qualify for plasma donation. This selection bias may have resulted in an underrepresentation of SARS-CoV-2 antibody positive individuals and of more severe COVID-19 cases in particular. Second, we asked participating individuals to report their symptoms over a period of almost three months, which obviously introduces a risk of recall bias. Nonetheless, given the unprecedented impact of SARS-CoV-2 on society and the repeated governmental calls to self-isolate with symptoms, we expect that most individuals have an exceptional recollection of their COVID-19 suspicion and symptoms during this period. As governments slowly ease virus control measures, it becomes vital to identify and isolate infected individuals to prevent new SARS-CoV-2 outbreaks.19,20 The presence of anosmia/dysgeusia, especially, should trigger PCR testing.17 In addition, our study confirms the existence of asymptomatic SARS-CoV-2 infections and adds that even symptomatic individuals did not suspect a SARS-CoV-2 infection. Despite the limitations of studies thus far, sufficient evidence of asymptomatic and pre-symptomatic transmission of SARS-CoV-2 exists.16,21 Efforts to identify cases that rely on symptoms may therefore be insufficient, which emphasizes the importance of thorough contact tracing.22 In conclusion, almost half of the individuals that tested positive for antibodies to SARS-CoV-2 in a reliable assay did not suspect having had an infection. This proportion may be lowered with better awareness and recognition of COVID-19 symptoms, in particular the loss of smell and taste. However, 38% of those infected reported no or only very mild symptoms. Tracing of asymptomatic contacts is therefore crucial to halting transmission.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
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