Identification of SARS-CoV-2 Vaccine Epitopes Predicted to Induce Long-Term Population-Scale Immunity
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SciScore for 10.1101/2020.03.31.018978: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
Software and Algorithms Sentences Resources All sequences were aligned using Clustal Omega (Sievers et al., 2011) and each position summed for homology. Clustal Omegasuggested: (Clustal Omega, RRID:SCR_001591)B cell Epitope Scoring: We used BepiPred 2.0 and DiscoTope 2.0 (Jespersen et al., 2017; Kringelum et al., 2012) to score individual amino acid residues, assessing linear epitopes in Matrix, Envelope, and Spike proteins, and conformational epitopes for Spike protein, based on published structure (PDB 6VYB). BepiPredsuggested: (BepiPred-2.0, RRID:SCR_018499)DiscoTopesuggested: (DiscoTope, RRID:SCR_018530)Results from OddPub: We …
SciScore for 10.1101/2020.03.31.018978: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
Software and Algorithms Sentences Resources All sequences were aligned using Clustal Omega (Sievers et al., 2011) and each position summed for homology. Clustal Omegasuggested: (Clustal Omega, RRID:SCR_001591)B cell Epitope Scoring: We used BepiPred 2.0 and DiscoTope 2.0 (Jespersen et al., 2017; Kringelum et al., 2012) to score individual amino acid residues, assessing linear epitopes in Matrix, Envelope, and Spike proteins, and conformational epitopes for Spike protein, based on published structure (PDB 6VYB). BepiPredsuggested: (BepiPred-2.0, RRID:SCR_018499)DiscoTopesuggested: (DiscoTope, RRID:SCR_018530)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- No conflict of interest statement was detected. If there are no conflicts, we encourage authors to explicit state so.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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