Real-world comparative effectiveness of mRNA-1273 and BNT162b2 vaccines among immunocompromised adults identified in administrative claims data in the United States
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SciScore for 10.1101/2022.05.13.22274960: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: This study was exempt from review by the New England Institutional Review Board (#1-9757—1). Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:The results of this study should be interpreted in light of several limitations. First, there remains the potential for residual confounding by unmeasured variables. Second, …
SciScore for 10.1101/2022.05.13.22274960: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: This study was exempt from review by the New England Institutional Review Board (#1-9757—1). Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:The results of this study should be interpreted in light of several limitations. First, there remains the potential for residual confounding by unmeasured variables. Second, identifying the primary outcome of medically-attended COVID-19 identified via the ICD-10 U-code for COVID-19 diagnosis in the inpatient or outpatient setting has not been previously validated specifically within the HealthVerity database. However, a recent study in the US Veterans Affairs database estimated the positive predictive value (PPV) of the ICD-10 code U07.1 in all settings (inpatient, outpatient, and emergency department/urgent care) to be 84.2% [36], which supports the robustness of this outcome and also cautiously noting the high PPV dependency associated with high disease prevalence within a pandemic setting. Furthermore, the analysis of an alternative definition of medically-attended COVID-19 requiring the presence of an antigen or polymerase chain reaction test produced an effect estimate slightly further from the null, thereby confirming the hypothesis that misclassification of the primary outcome would be non-differential between vaccine groups, with the resulting bias to be towards the null [37]. The difference in the HR between the base-case U code definition and the alternative definition requiring testing (0.05) is in line with our bias analysis based on the PPV estimate (see supplementary text and Figure S1). Additionally, in a real-world study of Ad26.COV2.S using the HealthVerity d...
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT05366322 Completed A Study to Compare mRNA-1273 Versus BNT162b2 COVID-19 Vaccin… Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a protocol registration statement.
Results from scite Reference Check: We found no unreliable references.
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