Vaccine-induced humoral response against SARS-CoV-2 dramatically declined but cellular immunity possibly remained at 6 months post BNT162b2 vaccination

  1. Hideaki Kato
  2. Kei Miyakawa
  3. Norihisa Ohtake
  4. Yutaro Yamaoka
  5. Satoshi Yajima
  6. Etsuko Yamazaki
  7. Tomoko Shimada
  8. Atsushi Goto
  9. Hideaki Nakajima
  10. Akihide Ryo

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Abstract

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  1. Version published to 10.1016/j.vaccine.2022.03.057
  2. ScreenIT

    SciScore for 10.1101/2021.10.30.21265693: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsConsent: In this study, written informed consent was obtained independently to participate in this study from each participant.
    IRB: This study was approved by the relevant institutional review board (approval number: B210800024).
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Antibodies
    SentencesResources
    Immunoglobulin G titer against SP and nucleocapsid (NP) IgG were determined using the commercial chemiluminescent enzyme immunoassay (AIA-CL SARS-CoV-2 SP IgG antibody detection reagent, Tosoh, Japan).
    NP) IgG
    suggested: None
    SARS-CoV-2 SP IgG
    suggested: None
    Software and Algorithms
    SentencesResources
    Then, 50% neutralizing titer (NT50) values were calculated using the Image J software (NIH).
    Image J
    suggested: (ImageJ, RRID:SCR_003070)
    Statistical analyses were performed using the Prism 9.1 (GraphPad Software, San Diego, CA, USA) and JMP Pro 15 software (SAS Institute, Cary, NC, USA).
    Prism
    suggested: (PRISM, RRID:SCR_005375)
    GraphPad
    suggested: (GraphPad Prism, RRID:SCR_002798)
    SAS Institute
    suggested: (Statistical Analysis System, RRID:SCR_008567)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    This study has several limitations. For instance, the data on SP-specific T-cell response immediately after the vaccination was lacking and the sample size of the cohort was small. In addition, generally, cellular immunity is weakened in elderly and immunosuppressed individuals. However, our study demonstrated that antibody titers do not necessarily correlate well with cellular immunity, indicating that the dynamics of cellular immunity are different from those of humoral immunity and suggesting that the evaluation of cellular immunity is warranted for long-term evaluation of the efficacy of SARS-CoV-2 vaccines.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2021.10.30.21265693v1 on medRxiv