Early effectiveness of BNT162b2 Covid-19 vaccine in preventing SARS-CoV-2 infection in healthcare personnel in six Israeli hospitals (CoVEHPI)
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SciScore for 10.1101/2021.08.30.21262465: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: Ethics: The study protocol was reviewed and approved by the CHS Central Institutional Review Board All participants completed written informed consent in Hebrew.
Consent: Ethics: The study protocol was reviewed and approved by the CHS Central Institutional Review Board All participants completed written informed consent in Hebrew.Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Antibodies Sentences Resources Because the latter two anti-spike protein antibody tests were likely to be positive for vaccinated participants, we only used results from the Abbott SARS-CoV-2 nucleocapsid IgG test to determine new … SciScore for 10.1101/2021.08.30.21262465: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: Ethics: The study protocol was reviewed and approved by the CHS Central Institutional Review Board All participants completed written informed consent in Hebrew.
Consent: Ethics: The study protocol was reviewed and approved by the CHS Central Institutional Review Board All participants completed written informed consent in Hebrew.Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Antibodies Sentences Resources Because the latter two anti-spike protein antibody tests were likely to be positive for vaccinated participants, we only used results from the Abbott SARS-CoV-2 nucleocapsid IgG test to determine new infections. anti-spike proteinsuggested: NoneSoftware and Algorithms Sentences Resources Data Management: Data collection and management for the study were conducted using REDCap, a browser-based software system (Vanderbilt University, Nashville, TN, USA). REDCapsuggested: (REDCap, RRID:SCR_003445)(Supplemental Methods 1) Serology: Enrollment serology samples underwent testing at either one of the study hospitals or the CHS Central Laboratory for antibodies to SARS-CoV-2 using a combination of the Abbott SARS-CoV-2 nucleocapsid IgG test (Abbott Laboratories, Sligo, Ireland), the Liaison SARS-CoV-2 spike protein S1/S2 IgG test (DiaSorin, Centralino, Italy), and the Abbott SARS-CoV-2 IgG II Quant test (Abbott Laboratories, Sligo, Ireland). Abbott Laboratoriessuggested: NoneSerology specimens collected at 30 days and 90 days were tested with the Abbott SARS-CoV-2 nucleocapsid IgG test and either the Abbott SARS-CoV-2 IgG II Quant test or the Liaison SARS-CoV-2 spike protein S1/S2 IgG test. Abbottsuggested: (Abbott, RRID:SCR_010477)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our study has a number of limitations. First, because participation was voluntary, it may suffer from selection bias, which may limit its generalizability; participants who chose to participate likely differed from the broader HCP population and the overall Israeli population in quantifiable and unquantifiable ways. Second, vaccinated and unvaccinated participants differed with respect to a number of demographic characteristics. We did, however, adjust for many of these differences, such as sex, SES and occupation in our analyses. Third, we used different combinations of serology testing to determine enrollment serological status. Differences in sensitivities of different test combinations may have created inconsistencies in serological status determination. In addition, while the serological test (Abbott SARS-CoV-2 nucleocapsid IgG test) we used to determine new infections during the 30- to 90-day follow-up window has been shown to be over 90% sensitive in identifying PCR infections in mildly symptomatic individuals,26 it may be less sensitive in capturing asymptomatic individuals, and if so we may have missed some asymptomatic cases. In conclusion, in our prospective study of HCP across six hospitals in Israel with rigorous weekly surveillance, we found very high VE following two doses of Pfizer BNT162b2 mRNA vaccine against both symptomatic and asymptomatic SARS-CoV-2 during a period of predominant alpha variant circulation. While these results are encouraging, continued m...
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04709003 Recruiting Covid-19 Vaccine Effectiveness in Healthcare Personnel in Cl… Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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