Missed childhood immunizations during the COVID-19 pandemic in Brazil: Analyses of routine statistics and of a national household survey

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Abstract

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  1. SciScore for 10.1101/2020.11.30.20240911: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIRB: Ethical approval was granted by Brazil’s National Ethics Committee (process number CAAE 30721520.7.1001.5313), with written informed consent from all participants; for children and adolescents, consent was sought from parents or guardians.
    Consent: Ethical approval was granted by Brazil’s National Ethics Committee (process number CAAE 30721520.7.1001.5313), with written informed consent from all participants; for children and adolescents, consent was sought from parents or guardians.
    RandomizationWithin each city, 25 census tracts were chosen with probability proportionate to size, and 10 households were randomly selected per tract based on listings prepared by the Brazilian Institute of Geography and Statistics.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    Routine vaccination data: The first data source were routine reports on the number of vaccine doses administered to young children in the country, based on the National Immunization Program Information System (PNI) of the Brazilian Ministry of Health.
    National Immunization Program Information System
    suggested: None

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).


    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    Our analyses have limitations. The definitions of missed vaccinations based on the national information system and on the household survey are different, yet both sources suggest that about one in five children missed vaccinations. Coverage of the national information system is high, but there are delays in reporting from primary care facilities; nevertheless, it is unlikely that delays can explain the present findings of a clear dip during two calendar months and return to previous levels afterwards, as well as the finding that vaccines delivered primarily in hospitals were not affected. The response rate in the national survey was low, at around 55%, which is explained by the fact that many homes were empty as families attempted to move away from large cities due to the pandemic, as well as by refusals to receive interviewers due to fear of infection. Although the sample included all regional hub cities in the country, it is not representative of smaller towns and rural areas, where vaccine coverage may be different. On the other hand, the strengths of our analyses include the use of two different data sources that provided consistent results on levels and patterns of missed vaccinations. Due to the national scope of our study in a country with 220,000,000 inhabitants, it represents the largest assessment so far on how the COVID-19 pandemic has affected immunizations in a low- or middle-income country. Although the national data suggest that vaccine administration has retur...

    Results from TrialIdentifier: No clinical trial numbers were referenced.


    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


    Results from JetFighter: We did not find any issues relating to colormaps.


    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

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