Logistic advantage of two-step screening strategy for SARS-CoV-2 at airport quarantine

  1. Isao Yokota
  2. Peter Y. Shane
  3. Takanori Teshima

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Abstract

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  1. Version published to 10.1016/j.tmaid.2021.102127
  2. ScreenIT

    SciScore for 10.1101/2021.01.25.21250509: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIRB: This study was approved by the Institutional Ethics Board (Hokkaido University Hospital Division of Clinical Research Administration Number: 020-0116) and anonymously processed data were provided by the quarantine stations.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    LAMP was carried out to detect SARS-CoV-2 RNA using Loopamp® □ 2019-SARS-CoV-2 Detection Reagent Kit (Eiken Chemical, Tokyo, Japan) and the Loopamp Real-time Turbidimeter (Eiken Chemical) as previously described14.
    LAMP
    suggested: (LAMP, RRID:SCR_001740)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    The main limitation of our study was the lack of clinical information after screening to assess the rates of observed false positivity. Post-screening investigation of more than 80,000 persons was simply out of the scope of this study. An additional limitation was that the probability of CLEIA-positive given NAAT-positive could not be validated, as NAAT was not performed for CLEIA-negative samples (antigen levels below 0·67pg/mL). Finally, although not truly a limitation of our study, we alluded to NAAT positivity as infectiousness, whereas this may not be true in cases of high Ct values28, 29. In summary, we examined the data from mass screening of more than 88,000 persons at airport quarantines and showed the effectiveness of the two-step strategy. We believe the logistic advantage of reducing the burden of NAAT by approximately 95% far outweigh the cost of slightly higher imported cases of false negatives. Two-step testing by CLEIA followed by NAAT is effective in real-world situations, especially when combined with appropriately timed pre-departure testing and/or with quarantine optimized with repeat testing.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2021.01.25.21250509v1 on medRxiv