Allosteric perspective on the mutability and druggability of the SARS-CoV-2 Spike protein
This article has been Reviewed by the following groups
Listed in
- Evaluated articles (ScreenIT)
Abstract
Article activity feed
-
-
SciScore for 10.1101/2021.08.01.454696: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
Software and Algorithms Sentences Resources Integrative Homology Modelling: Modeller version 9.21 (Sali and Blundell, 1993) was used to build two full length models of SARS-CoV-2 S protein: i) open state with one RBD in the up conformation and two RBDs in the down conformation; and ii) closed state with all three RBDs in the down conformation. Modellersuggested: (MODELLER, RRID:SCR_008395)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the …SciScore for 10.1101/2021.08.01.454696: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
Software and Algorithms Sentences Resources Integrative Homology Modelling: Modeller version 9.21 (Sali and Blundell, 1993) was used to build two full length models of SARS-CoV-2 S protein: i) open state with one RBD in the up conformation and two RBDs in the down conformation; and ii) closed state with all three RBDs in the down conformation. Modellersuggested: (MODELLER, RRID:SCR_008395)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
-
