Incidence of COVID-19 in a cohort of adult and paediatric patients with rheumatic diseases treated with targeted biologic and synthetic disease-modifying anti-rheumatic drugs

  1. Xabier Michelena
  2. Helena Borrell
  3. Mireia López-Corbeto
  4. María López-Lasanta
  5. Estefanía Moreno
  6. María Pascual-Pastor
  7. Alba Erra
  8. Mayte Serrat
  9. Esther Espartal
  10. Susana Antón
  11. Gustavo Adolfo Añez
  12. Raquel Caparrós-Ruiz
  13. Andrea Pluma
  14. Ernesto Trallero-Araguás
  15. Mireia Barceló-Bru
  16. Miriam Almirall
  17. Juan José De Agustín
  18. Jordi Lladós
  19. Antonio Julià
  20. Sara Marsal

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Abstract

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  1. Version published to 10.1016/j.semarthrit.2020.05.001
  2. ScreenIT

    SciScore for 10.1101/2020.04.30.20086090: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    Analyses were performed with STATA v 16.0 and RStudio v.3.5.1.
    STATA
    suggested: (Stata, RRID:SCR_012763)
    RStudio
    suggested: (RStudio, RRID:SCR_000432)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    Some limitations of this study need to be addressed. First, we designed an observational study based on a telephone survey with different date completion and filled by distinct operators. Patient reporting could have been influenced by the operator and symptoms could have been missed as these could have appeared after the date of completion. To address this potential bias, we reviewed the electronic health records of all patients to detect possible cases and asked all our patients to actively contact us if any of the compatible symptoms occurred. Secondly, we only included rheumatic patients treated with tDMARDs without a control group, either treated with other type of DMARDs or untreated patients. Thirdly, our study is mainly focused on chronic inflammatory arthritis and we did not include, for example, patients with systemic lupus erythematosus or giant cell arteritis that could provide additional insights into the protective effect of hydroxychloroquine and anti-IL6 therapies. Further, the lockdown effect might be more pronounced in IMID patients since they are considered an immunosuppressed cohort protecting them from possible exposure to infection and, therefore, distorting their comparison with general population. With regards to the analysis, the small number of cases did not allow for the adjustment for potential confounders other than age and sex. Lastly, due to limited availability of SARS-CoV-2 testing in our setting, the estimate of COVID-19 incidence is inaccura...

    Results from TrialIdentifier: We found the following clinical trial numbers in your paper:

    IdentifierStatusTitle
    NCT04320615CompletedA Study to Evaluate the Safety and Efficacy of Tocilizumab i…
    NCT04324021TerminatedEfficacy and Safety of Emapalumab and Anakinra in Reducing H…

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2020.04.30.20086090v1 on medRxiv