The clinical and economic value of a successful shutdown during the SARS-CoV-2 pandemic in Germany

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Abstract

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  1. SciScore for 10.1101/2020.05.12.20098996: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    NIH rigor criteria are not applicable to paper type.

    Table 2: Resources

    No key resources detected.


    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).


    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    As a word of caution, given the time constraints and the ongoing inflow of new information on the SARS-CoV-2 pandemic while conducting the study and writing this manuscript, which made it pertinent to continuously update the projections, this modeling study has several caveats as discussed below. Given the clear direction of its results, however, it could still provide important guidance for policymakers, which is outlined further below. First, there are reasons why the base case overestimates the projected health benefits of a shutdown and the corresponding monetary value. Some of these reasons were already described in the sensitivity analysis and include an overestimate of CFR due to a large number of undetected cases. In addition, the study does not consider the deaths and loss of health-related quality of life associated with the shutdown and social distancing, e.g., due to depressive or anxiety disorders, suicides, unemployment, domestic violence, and fewer emergency and physician visits for unrelated medical conditions. Nevertheless, official data on excess mortality in Germany (Federal Office of Statistics 2020) show that both excess mortality and COVID-19 mortality peaked in the first half of April, thus indicating that excess mortality was driven by COVID-19 and not by other causes. Furthermore, ICU survivors may suffer from a loss of quality of life (Needham 2013). Moreover, unaffected individuals may experience a loss of personal freedom (Abele-Brehm 2020) and aut...

    Results from TrialIdentifier: No clinical trial numbers were referenced.


    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


    Results from JetFighter: We did not find any issues relating to colormaps.


    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

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