Healthcare workers benefit from second dose of COVID-19 mRNA vaccine: Effects of partial and full vaccination on sick leave duration and symptoms

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Abstract

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  1. SciScore for 10.1101/2021.11.17.21266479: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsIRB: The study was approved by the University of Southern California Institutional Review Board.
    Sex as a biological variableData analysis: HCWs with return-to-work times > 100 days were excluded from the analytic sample because they represented special circumstances (e.g., employees who took extended leave because they were pregnant or caring for sick family members).
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    No key resources detected.


    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).


    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    Limitations: This study was conducted in early 2021, before the more virulent delta variant proliferated in the U.S.5 It is unclear whether the findings would be similar with the delta variant. Because of the increased risk of serious illness, hospitalization and transmission resulting from the Delta variant, had this study been conducted six months later, our results might have differed in the number of vaccine breakthroughs and possibly duration/severity of illness. It is also uncertain at this time whether waning immunity over time will increase return-to-work time among vaccinated HCWs. However we still believe that those who were fully vaccinated will still return to work more rapidly although the duration may be different and they will have a better overall outcome than those who are not vaccinated. Conclusion: These findings underscore the benefits of COVID-19 vaccination in reducing convalescent time and symptom severity, with fully vaccinated HCWs recovering more quickly and with a much greater likelihood of having no or milder symptoms. This has implications for public health and for a specific institution, both in terms of institutional costs and overall population health.

    Results from TrialIdentifier: No clinical trial numbers were referenced.


    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


    Results from JetFighter: We did not find any issues relating to colormaps.


    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.


    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.