Chansu improves the respiratory function of severe COVID-19 patients

  1. Fen Hu
  2. Jiao Chen
  3. Hao Chen
  4. Jin Zhu
  5. Chen Wang
  6. Haibin Ni
  7. Jianming Cheng
  8. Xingxing Hu
  9. Peng Cao

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Abstract

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  1. Version published to 10.1016/j.prmcm.2021.100007
  2. ScreenIT

    SciScore for 10.1101/2020.05.20.20107607: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIRB: From February 5, 2020 to March 5, 2020, a total of 50 patients with severe or critical severe COVID-19 admitted to the department of Respiratory and Critical Care Medicine of The First People’s Hospital of Jiangxia District, Wuhan, China were enrolled in the trial after approval by the ethics committees.
    Consent: Written informed consent was obtained from all patients or from the patient’s legal representative.
    RandomizationStudy Design and Participants: A prospective randomized controlled study was conducted.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variableMain exclusion criteria included age <7 years old, pregnant female, history of arrhythmia, chronic respiratory failure caused by other diseases, such as heart failure, thoracic deformity, structural lung disease, etc., hemodynamic instability, severe immunodeficiency or using immunosuppressants recently, allergies, estimated survival time <3 days, withdrawal from research or return visits.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    Statistical Analysis: All data analyses were performed in SPSS 22.0.
    SPSS
    suggested: (SPSS, RRID:SCR_002865)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    This clinical trial conducted in such an emergency has several limitations. Firstly, the trial was not blinded, which might influence clinical decision-making. Secondly, because of limited conditions, the effect of virologic clearance was not tested after 7 days treatment. We can only use the outcomes of respiratory function such as PaO2/FiO2 and ROX index to evaluate the efficacy of Chansu injection. Thirdly, some patients had a history of out-of-hospital treatment, leading to the inconsistency of disease course. Interventions not being able to carried out at the same time after the patients transformed from mild symptoms to severe symptoms may lead to biased results. Other limitations include a small sample size and limited long-term outcome follow-up. In conclusion, we found that Chansu has apparent efficacy in treating severe COVID-19 in this preliminary study. It can improve the patients’ respiratory function significantly. These promising early data provide a reference for the treatment of severe COVID-19.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2020.05.20.20107607 on medRxiv