Post-infection depressive, anxiety and post-traumatic stress symptoms: A prospective cohort study in patients with mild COVID-19

  1. Flavia Ismael
  2. João C.S. Bizario
  3. Tatiane Battagin
  4. Beatriz Zaramella
  5. Fabio E. Leal
  6. Julio Torales
  7. Antonio Ventriglio
  8. Megan E. Marziali
  9. Silvia S. Martins
  10. João M. Castaldelli-Maia

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Abstract

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  1. Version published to 10.1016/j.pnpbp.2021.110341
  2. ScreenIT

    SciScore for 10.1101/2020.08.25.20182113: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIRB: Ethical Approval: The present study was approved by the local ethics committee (Comissão de Ética para Análise de Projeto de Pesquisa - CAPPesq, protocol No. 32293020.9.0000.5510, approved on July 13th, 2020). 2.2.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variableAll pregnant women, and patients meeting pre-defined triage criteria for severe disease, were advised to attend a hospital service - either an emergency department or outpatient service, depending on availability.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    Statistical Analysis: STATA software version 16.2 was used to run the analysis.
    STATA
    suggested: (Stata, RRID:SCR_012763)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    Strengths and Limitations: Assessing people for depressive, anxiety, and post-traumatic stress symptoms at different timepoints should be noted as an important limitation of the present study. However, we adjusted all the logistic regression and GLM models to the time of assessment and also conducted sensitivity analyses, excluding those who could potentially be assessed during the acute phase of COVID-19 and testing whether the continuous or categorical version. We were also not able to assess other important behavioral disorders (i.e., substance use and sleep disorders). However, we were able to assess the most prevalent disorders following traumatic experiences in almost a thousand COVID-19 patients through reliable measures both for exposure and outcomes, with an acceptable response rate. The patients included in the present study were slightly different from those who did not attend the invitation. Despite the latter being older, no significant difference was found for the total number of COVID-19 symptoms, which was our exposure measure. The main issue for generalization of our findings was the inclusion of individuals dependent on the public healthcare sector only. 4.2. Conclusion: Exposure to increased levels of COVID-19 symptomatology may predispose individuals to clinically significant levels of depressive, anxiety and post-traumatic stress symptoms after the acute phase of the disease, independently of previous psychiatric diagnosis. These patients should be monito...

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2020.08.25.20182113v2 on medRxiv
  4. Version published to 10.1101/2020.08.25.20182113v1 on medRxiv