Differences in risk for SARS-CoV-2 infection among healthcare workers

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Abstract

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  1. SciScore for 10.1101/2021.03.30.21254653: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementConsent: Participants signed a written informed consent that included permission to link to the hospital administrative databases for information on professional role (physician, nurse/midwife, nurse assistant, or other), sick leave records and hospital unit assignment (s).
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.
    Cell Line Authenticationnot detected.

    Table 2: Resources

    Antibodies
    SentencesResources
    SARS-CoV-2 IgG antibodies were analysed using three different virus protein variants, namely the trimeric full-length Spike protein (14) expressed in HEK cells, the Spike S1 domain expressed in CHO cells and the Nucleocapsid protein expressed in E. coli.
    SARS-CoV-2 IgG
    suggested: None
    Captured IgG antibodies were detected by fluorescent anti-hIgG (Invitrogen, H10104) and reported as relative fluorescence intensity (AU).
    anti-hIgG
    suggested: (Antibodies-Online Cat# ABIN288163, RRID:AB_10795674)
    Experimental Models: Cell Lines
    SentencesResources
    SARS-CoV-2 IgG antibodies were analysed using three different virus protein variants, namely the trimeric full-length Spike protein (14) expressed in HEK cells, the Spike S1 domain expressed in CHO cells and the Nucleocapsid protein expressed in E. coli.
    HEK
    suggested: CLS Cat# 300192/p777_HEK293, RRID:CVCL_0045)
    CHO
    suggested: CLS Cat# 603479/p746_CHO, RRID:CVCL_0213)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).


    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: We found the following clinical trial numbers in your paper:

    IdentifierStatusTitle
    NCT04411576RecruitingCurrent and Past SARS-CoV-2 Infection and COVID-19 in Health…


    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


    Results from JetFighter: We did not find any issues relating to colormaps.


    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.