Blood omega-3 fatty acids and death from COVID-19: A pilot study
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SciScore for 10.1101/2021.01.06.21249354: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis Power analysis: A sample size of 100 provided 80% power to detect a 10-fold difference in death risk between any quartile of the O3I and any other quartile, after adjusting for other variables and using an exploratory significance level of 0.10. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the …SciScore for 10.1101/2021.01.06.21249354: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis Power analysis: A sample size of 100 provided 80% power to detect a 10-fold difference in death risk between any quartile of the O3I and any other quartile, after adjusting for other variables and using an exploratory significance level of 0.10. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Limitations: Given the pilot nature of this exploratory study, a number of limitations are acknowledged. Firstly, the sample size was small. Secondly, the limited resources and resulting access to the full electronic medical record for more detailed chart review significantly reduced the amount of potentially relevant information on comorbidities and other demographic data besides age and sex (e.g., BMI). Although data on maximal interventions applied during hospitalization were available, the reasons why any given patient was administered a given treatment are not known and could obviously have been influenced by external factors (e.g., ventilator availability) or internal factors (e.g., a DNR order). Accordingly, such information was deemed to be of little utility in this pilot study. The population of patients in this study had an O3I that was typical of the US [28], which unfortunately means that levels were generally low. Future studies should endeavor to include patients with a wider range of O3I to examine these relationships more clearly. 4.2. Conclusions: Given the profound public health concerns related to the current COVID-19 pandemic, modifiable risk factors for developing severe and critical complications are urgently needed. Despite the known mechanisms by which IRMs and omega-3 fatty acids support the active, endogenous resolution of inflammatory mechanisms, to our knowledge this is the first study that has explored the relationship between omega 3 tissue level...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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SciScore for 10.1101/2021.01.06.21249354: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis Power analysis A sample size of 100 provided 80% power to detect a 10-fold difference in death risk between any quartile of the O3I and any other quartile, after adjusting for other variables and using an exploratory significance level of 0.10. Sex as a biological variable Unadjusted associations of the Omega-3 Index and demographic variables with death Risk factor Death % (x/N) Sex Female Male Unadjusted Models OR (95% CI)1 Firth’s test P-value1 14.6% (6/41) 13.6% (8/59) Age Per decade 1.00 0.90 (0.30 Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect …
SciScore for 10.1101/2021.01.06.21249354: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis Power analysis A sample size of 100 provided 80% power to detect a 10-fold difference in death risk between any quartile of the O3I and any other quartile, after adjusting for other variables and using an exploratory significance level of 0.10. Sex as a biological variable Unadjusted associations of the Omega-3 Index and demographic variables with death Risk factor Death % (x/N) Sex Female Male Unadjusted Models OR (95% CI)1 Firth’s test P-value1 14.6% (6/41) 13.6% (8/59) Age Per decade 1.00 0.90 (0.30 Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
Limitations. Given the pilot nature of this exploratory study, a number of limitations are acknowledged. Firstly, the sample size was small. Secondly, the limited resources and resulting access to the full electronic medical record for more detailed chart review significantly reduced the amount of potentially relevant information on comorbidities and other demographic data besides age and sex (e.g., BMI). Although data on maximal interventions applied during hospitalization were available, the reasons why any given patient was administered a given treatment are not known and could obviously have been influenced by external factors (e.g., ventilator availability) or internal factors (e.g., a DNR order). Accordingly, such information was deemed to be of little utility in this pilot study. The population of patients in this study had an O3I that was typical of the US [28], which unfortunately means that levels were generally low. Future studies should endeavor to include patients with a wider range of O3I to examine these relationships more clearly.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
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