Evaluation of vertical transmission of SARS-CoV-2 in utero: Nine pregnant women and their newborns
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Abstract
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SciScore for 10.1101/2020.12.28.20248874: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement Consent: Treatments were informed to the patient and consent was obtained.
IRB: Ethical approval for the study was obtained from the Ethics Committee of Wuhan Union and Tongji hospitals of Huazhong University of Science and Technology.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable Case acquisition: The positive placenta tissue came from the pregnant women who were diagnosed with COVID-19 from Tongji and Union Hospital, Huazhong University of Science and Technology, Wuhan. Table 2: Resources
Antibodies Sentences Resources , IL) with ACE2 Monoclonal Antibody (ab15348 [2ug/mL], abcam) ACE2suggested: (Abcam Cat# …SciScore for 10.1101/2020.12.28.20248874: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement Consent: Treatments were informed to the patient and consent was obtained.
IRB: Ethical approval for the study was obtained from the Ethics Committee of Wuhan Union and Tongji hospitals of Huazhong University of Science and Technology.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable Case acquisition: The positive placenta tissue came from the pregnant women who were diagnosed with COVID-19 from Tongji and Union Hospital, Huazhong University of Science and Technology, Wuhan. Table 2: Resources
Antibodies Sentences Resources , IL) with ACE2 Monoclonal Antibody (ab15348 [2ug/mL], abcam) ACE2suggested: (Abcam Cat# ab15348, RRID:AB_301861), CD147 Monoclonal Antibody (ab15348 [2ug/mL], abcam) and GRP78 Monoclonal Antibody (promab). CD147suggested: NoneGRP78suggested: NoneSARS-CoV-2 nucleocapsid protein and spike protein monoclonal antibodies were produced by our cooperation with ProMab Biotechnologies, the antibody specificity has been verified by SDS-PAGE and elisa. spike protein monoclonal antibodiessuggested: NoneExperimental Models: Organisms/Strains Sentences Resources (For protein information, see Supplementary Table S1 and Figure S1) Immunized animals: Each tumor-associated marker antigen immunized 5 BALB/C mice (male and female) aged 8 ∼ 12 weeks. BALB/Csuggested: RRID:IMSR_ORNL:BALB/cRl)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:However, there were still some limitations in our study, on the one hand, there were only seven cases of positive pregnant women, which might be biased when analyzing the results, on the other hand, we lack cord blood and newborn blood samples. According to the classification of clinical cases, if RT-PCR results are positive in umbilical cord and newborn blood samples, it is even more reasonable to believe that the infection originates from the transmission of the positive pregnant woman to the fetus through the placenta [11].
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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