Covid-19 in Parkinson's Disease treated by drugs or brain stimulation
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SciScore for 10.1101/2021.03.03.21252464: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Study Design and Population: This cross-sectional, case-control study was approved by the Iran National Committee for Ethics in Biomedical Researches (IR.SBMU.RETECH.REC.1398.439) to investigate Covid-19 prevalence and death rate its clinical features, and further consequences in Parkinson’s disease patients compared to the general population.
Consent: After obtaining informed consent from all patients, a questionnaire which was prepared for the patients, consists of demographic data, medical history, and detailed PD-related and Covid-19-related clinical information of the patients, was completed over the phone call.Randomization not detected. Blinding not … SciScore for 10.1101/2021.03.03.21252464: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Study Design and Population: This cross-sectional, case-control study was approved by the Iran National Committee for Ethics in Biomedical Researches (IR.SBMU.RETECH.REC.1398.439) to investigate Covid-19 prevalence and death rate its clinical features, and further consequences in Parkinson’s disease patients compared to the general population.
Consent: After obtaining informed consent from all patients, a questionnaire which was prepared for the patients, consists of demographic data, medical history, and detailed PD-related and Covid-19-related clinical information of the patients, was completed over the phone call.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Statistical analysis was done with Excel Microsoft office, and R language (4.0.2 ed,2020) implemented in R studio (1.3.1093 ed,2020). Excelsuggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:The current condition also imposes limitations which may lead to deterioration in PD clinical course. Reduction in physical activity during quarantine may lead to worsening of both motor and non-motor symptoms as exercise may attenuate clinical symptom progression in PD [13]. Availability of PD medications, health services, and physicians’ advice or guidance during the lockdowns is recognized as an important factor in the deterioration of the clinical course of PD patients. In this sense, disability in PD patients may increase due to a lack of access to suitable and sufficient medications. This condition may lead to an increase in motor, non-motor, and neuropsychiatric symptoms and possibly higher mortality [17, 18]. In our study, 32.92%, 38.65%, and 41.09% of PD patients, PD patients who had undergone a DBS surgery, and PD patients who were infected with Covid-19 reported worsening of motor symptoms. However, we could not find any significant between Covid-19 infection and worsening of motor symptoms or between DBS surgery and worsening of motor symptoms. Moreover, we could not find any association between a deterioration in psychological status and Covid-19 in PD patients. Such association could not also be found between anxiety and Covid-19 and sleeping disorders and Covid-19. But interestingly, the normal population demonstrated higher levels of deterioration in psychological status, anxiety, and sleeping disorders than PD patients. Since our normal population was signifi...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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