Covid-19 in Parkinson's Disease treated by drugs or brain stimulation

  1. M. Salari
  2. M. Etemadifar
  3. A. Zali
  4. Z. Aminzade
  5. I. Navalpotro-Gomez
  6. S. Tehrani Fateh

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Abstract

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  1. Version published to 10.1016/j.nrl.2021.07.002
  2. ScreenIT

    SciScore for 10.1101/2021.03.03.21252464: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIRB: Study Design and Population: This cross-sectional, case-control study was approved by the Iran National Committee for Ethics in Biomedical Researches (IR.SBMU.RETECH.REC.1398.439) to investigate Covid-19 prevalence and death rate its clinical features, and further consequences in Parkinson’s disease patients compared to the general population.
    Consent: After obtaining informed consent from all patients, a questionnaire which was prepared for the patients, consists of demographic data, medical history, and detailed PD-related and Covid-19-related clinical information of the patients, was completed over the phone call.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    Statistical analysis was done with Excel Microsoft office, and R language (4.0.2 ed,2020) implemented in R studio (1.3.1093 ed,2020).
    Excel
    suggested: None

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    The current condition also imposes limitations which may lead to deterioration in PD clinical course. Reduction in physical activity during quarantine may lead to worsening of both motor and non-motor symptoms as exercise may attenuate clinical symptom progression in PD [13]. Availability of PD medications, health services, and physicians’ advice or guidance during the lockdowns is recognized as an important factor in the deterioration of the clinical course of PD patients. In this sense, disability in PD patients may increase due to a lack of access to suitable and sufficient medications. This condition may lead to an increase in motor, non-motor, and neuropsychiatric symptoms and possibly higher mortality [17, 18]. In our study, 32.92%, 38.65%, and 41.09% of PD patients, PD patients who had undergone a DBS surgery, and PD patients who were infected with Covid-19 reported worsening of motor symptoms. However, we could not find any significant between Covid-19 infection and worsening of motor symptoms or between DBS surgery and worsening of motor symptoms. Moreover, we could not find any association between a deterioration in psychological status and Covid-19 in PD patients. Such association could not also be found between anxiety and Covid-19 and sleeping disorders and Covid-19. But interestingly, the normal population demonstrated higher levels of deterioration in psychological status, anxiety, and sleeping disorders than PD patients. Since our normal population was signifi...

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2021.03.03.21252464v1 on medRxiv