Conundrum of re-positive COVID-19 cases: A systematic review of case reports and case series

  1. Arun Kumar Yadav
  2. S. Ghosh
  3. Sudhir Dubey

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Abstract

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  1. Version published to 10.1016/j.mjafi.2021.05.025
  2. ScreenIT

    SciScore for 10.1101/2020.12.10.20223990: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    The databases that were searched included Medline through Pubmed, and Cochrane databases.
    Medline
    suggested: (MEDLINE, RRID:SCR_002185)
    Cochrane
    suggested: (Cochrane Library, RRID:SCR_013000)
    The detailed search for Pubmed is given in supplementary table 1.
    Pubmed
    suggested: (PubMed, RRID:SCR_004846)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    Howerver there is a limitation of making inference from the systematic review as no valid control group were not present and secondly the denominatior in case reports or case series is difficult to ascertain. The effect of other immunomodulator and antiviral drug on recurrence may be studied in well designed study. The pooled proportion of studies that have given the proportion of COVID 19 repositives was done. Around 12% of discharged COVID 19 cases after comes out positive. The reasons may be related to Intermittent shedding of virus, the persistence of the virus, testing technique including sampling, or host characteristics. The persistence of virus in body is known phenomenon for SARS-associated Coronavirus(36). As of now there was no evidence of secondary cases from these repositives, however, the possibility of spread of infection does exist. This underlines the importance of surveillance of discharge cases of COVID 19. Different site for sample may also have some effect as in many cases even if the sample from nasopharyngeal are negative, the samples from sputum (lower respiratory tract) and anal swab have been positive. There is an evidence that virus may be shed longer from extraphrangeal site. There are reports that of virus shedding from asymptomatic patients may continue from extrapulmonary sites in various bodily fluids (Saliva, tears, feaces, throat, or nasal discharge) for longer duration of time(37,38). Its role in re-infection is still not known. However ther...

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2020.12.10.20223990 on medRxiv