Impact of body composition on COVID-19 susceptibility and severity: A two-sample multivariable Mendelian randomization study
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SciScore for 10.1101/2020.07.14.20153825: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization Regarding the random allocation of single nucleotide polymorphisms (SNPs) at the offspring (independent of any confounders like gender and age and therefore no need for adjustment), this kind of instrumental variable analysis mimics a randomized controlled trial. Blinding not detected. Power Analysis Statistical power: The a priori statistical power for the binary traits susceptibility and hospitalization due to COVID-19 disease was calculated according to Burgess et al.[28]. Sex as a biological variable All datasets include observations in men and women of European ancestry. Table 2: Resources
Software and Algorithms Sentences Resources Substant… SciScore for 10.1101/2020.07.14.20153825: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization Regarding the random allocation of single nucleotide polymorphisms (SNPs) at the offspring (independent of any confounders like gender and age and therefore no need for adjustment), this kind of instrumental variable analysis mimics a randomized controlled trial. Blinding not detected. Power Analysis Statistical power: The a priori statistical power for the binary traits susceptibility and hospitalization due to COVID-19 disease was calculated according to Burgess et al.[28]. Sex as a biological variable All datasets include observations in men and women of European ancestry. Table 2: Resources
Software and Algorithms Sentences Resources Substantial heterogeneity within the IVW and MR-Egger methods was quantified and tested using Cochran’s as well as Rücker’s Q statistics [Table A.6]. Cochran’ssuggested: NoneResults from OddPub: Thank you for sharing your data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Strengths and limitations: Strengths of the study include that we performed a range of robust MR methods to conduct sensitivity analyses for different patterns of pleiotropy, investigated total and direct effects and assessed mediation mechanisms at once. The use of three body composition measures, that have different views on body fat distribution, allowed us to compare as well as differentiate between overall and abdominal fat content. Moreover, the used TFR summary level data, which based on exact measurement procedure instead of approximation, allowed us to verify the results of usually used WC-GWAS and on this way to strengthen the evidence. However, our study also has limitations. The relationship between obesity and the risk of acquiring COVID-19 disease is influenced by selection bias, because people with no, uncomplicated or milder symptoms often were not tested regarding SARS-CoV-2 infection. This causes bias towards the null hypothesis due to false negatives (type II error) and reduces therefore the power by underestimating the true causal effect. Unfortunately, neither age nor sex was available for the COVID-19 cohort, so it was not possible to perform stratified analyses. Furthermore, the present study was conducted in subjects of European ancestry and therefore the findings could not be applied to other ethnicities. 4.4. Conclusions: Our study is the first strengthening the evidence that overall and not abdominal obesity is causally associated with the susceptib...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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