Are there medium to short-term multifaceted effects of the airborne pollutant PM2.5 determining the emergence of SARS-CoV-2 variants?

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Abstract

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  1. SciScore for 10.1101/2021.06.27.21259602: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Ethicsnot detected.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    No key resources detected.


    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).


    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    A caveat to this study indicated that the short sampling time of ¼ hr–4 h might not be representative of the total air volume in the ward and the presence of SARS-CoV-2 might have possibly been diluted during air exchanges in the ward (Ong, S. W. et al. 2020). Another study in Northern Italy by Collovignarelli et al. put the association between particulate matter and COVID-19 in doubt. Collovignarelli et al. excluded a significant correlation between atmospheric particulate matter and the incidence of COVID-19. This latter study suggested that there may be other factors, including meteorological factors,that may have synergised with particulate matter to spread COVID-19. If one were to look closely at the provinces in Northern Italy as regards seeding and doubling time of COVID-19, the highest rates are to be found in land-locked provinces especially in Lodi, Bergamo, and Aosta. The impact of the vicinity to the sea as a factor determining COVID-19 rates has been alluded to (Muscat Baron 2020b) (Muscat Baron 2020c). By virtue of the absence of particulate matter sources from the sea, the level of this pollutant is likely to be lower and diluted in coastal provinces. Moreover the increased sodium chloride content in particulate matter derived from marine sources may have had a role in deterring the adhesion of the hydrophobic regions in the SARS-CoV-2 spike protein to particulate matter (Muscat Baron 2020c). One may surmise that the occurrence in the spikes of this pollutant i...

    Results from TrialIdentifier: No clinical trial numbers were referenced.


    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


    Results from JetFighter: We did not find any issues relating to colormaps.


    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.


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