Early multidrug treatment of SARS-CoV-2 infection (COVID-19) and reduced mortality among nursing home (or outpatient/ambulatory) residents

  1. Paul E. Alexander
  2. Robin Armstrong
  3. George Fareed
  4. John Lotus
  5. Ramin Oskoui
  6. Chad Prodromos
  7. Harvey A. Risch
  8. Howard C. Tenenbaum
  9. Craig M. Wax
  10. Parvez Dara
  11. Peter A. McCullough
  12. Kulvinder K. Gill

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Abstract

No abstract available

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  1. Version published to 10.1016/j.mehy.2021.110622
  2. ScreenIT

    SciScore for 10.1101/2021.01.28.21250706: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    RandomizationHaving said this, we also implore the medical community to consider that whilst in the midst of this terrible pandemic, we should not await, nor is there a need to await the completion of randomized controlled trials.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    For pragmatic reasons we searched PubMed/MEDLINE database for literature relevant to the question addressed here.
    PubMed/MEDLINE
    suggested: None
    MedCalc (https://www.softpedia.com/get/Science-CAD/MedCalc.shtml) was used to calculate odds ratios/relative risks and their 95% confidence intervals and p-values for mortality.
    MedCalc
    suggested: (MedCalc, RRID:SCR_015044)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    Limitations of This Study: Our report has all the limitations of reviews that extract data from multiple heterogeneous studies. We did focus on nursing home residents who are usually weaker and more infirmed that persons living independently in the community, making our results not applicable to community-dwelling adults. The reporting of early treatment in COVID-19 patients can be considered nascent and thus the number of available studies is limited as is their sample sizes. We relied on data presented in study reports, which in non-randomized studies may be subject to variable degrees of adjustment for potentially confounding factors. We assumed that the various studies and their study subjects were sufficiently similar to draw conclusions across them, and that the care facilities examined in the study reports are typical of such facilities in general and thus that the treatment benefits that we observed apply to nursing home and similar care facilities quite generally.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2021.01.28.21250706v1 on medRxiv