Outcomes of Hydroxychloroquine Usage in United States Veterans Hospitalized with COVID-19
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SciScore for 10.1101/2020.04.16.20065920: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: This study was conducted in compliance with the Department of Veterans Affairs requirements, received VA Institutional Review Board, and VA Research & Development approval. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources 16 Statistical analyses were performed with the use of SAS software, version 9.4 (SAS Institute) and R software, version 3.6.1 (the R project [http://r-project.org]). SAS Institutesuggested: (Statistical Analysis System, RRID:SCR_008567)Results from OddPub: We did not detect open data. We also did not detect open …
SciScore for 10.1101/2020.04.16.20065920: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: This study was conducted in compliance with the Department of Veterans Affairs requirements, received VA Institutional Review Board, and VA Research & Development approval. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources 16 Statistical analyses were performed with the use of SAS software, version 9.4 (SAS Institute) and R software, version 3.6.1 (the R project [http://r-project.org]). SAS Institutesuggested: (Statistical Analysis System, RRID:SCR_008567)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our study has certain limitations including those inherent to all retrospective analyses such as non-randomization of treatments. We did, however adjust for a large number of Covid-19-relevant confounders including comorbidities, medications, clinical and laboratory abnormalities. Despite propensity score adjustment for a large number of relevant confounders, we cannot rule out the possibility of selection bias or residual confounding. Our study cohort comprised only men whose median age was over 65 years. Therefore, the results may not necessarily reflect outcomes in women or in younger hospitalized populations, nor can they be extrapolated to pediatric patients. Our findings may also be influenced by the demographic composition of patients in our cohort, the majority of whom were black. Disproportionately higher rates of Covid-19-related hospitalization among the black population have also been reported in the United States as a whole.21 Our study also has certain strengths. Because we studied data from a comprehensive electronic medical record rather than from an administrative health insurance claims database, we used rigorously identified covariates and outcomes. We studied patients in an integrated national healthcare system; therefore, the data are less susceptible to biases of single-center or regional studies. Data from ongoing, randomized controlled studies will prove informative when they emerge. Until then, the findings from this retrospective study suggest cautio...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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SciScore for 10.1101/2020.04.16.20065920: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement , received VA Institutional Review Board , and VA Research & Development approval. Randomization These findings highlight the importance of awaiting the results of ongoing prospective, randomized, controlled studies before widespread adoption of these drugs. Blinding not detected. Power Analysis not detected. Sex as a biological variable Because the number of female patients in this cohort ( 17 ) was too small to permit robust statistical analyses , we evaluated the remaining 368 male patients in this study . Table 2: Resources
Software and Algorithms Sentences Resources 16 Statistical analyses were performed with the use of SAS software , version 9.4 ( SAS … SciScore for 10.1101/2020.04.16.20065920: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement , received VA Institutional Review Board , and VA Research & Development approval. Randomization These findings highlight the importance of awaiting the results of ongoing prospective, randomized, controlled studies before widespread adoption of these drugs. Blinding not detected. Power Analysis not detected. Sex as a biological variable Because the number of female patients in this cohort ( 17 ) was too small to permit robust statistical analyses , we evaluated the remaining 368 male patients in this study . Table 2: Resources
Software and Algorithms Sentences Resources 16 Statistical analyses were performed with the use of SAS software , version 9.4 ( SAS Institute ) and R software , version 3.6.1 ( the R project [ http://r-project.org]). SAS Institutesuggested: (Statistical Analysis System, SCR_008567)JA is a co-founder of iVeena Holdings , iVeena Delivery Systems and Inflammasome Therapeutics , and has received consultancy fees from Allergan , Biogen , Boehringer Ingelheim , Immunovant , Janssen , Olix Pharmaceuticals , Retinal Solutions , and Saksin LifeSciences , all unrelated to this work . Biogensuggested: (Biogen Idec, SCR_003790)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
About SciScore
SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore is not a substitute for expert review. SciScore checks for the presence and correctness of RRIDs (research resource identifiers) in the manuscript, and detects sentences that appear to be missing RRIDs. SciScore also checks to make sure that rigor criteria are addressed by authors. It does this by detecting sentences that discuss criteria such as blinding or power analysis. SciScore does not guarantee that the rigor criteria that it detects are appropriate for the particular study. Instead it assists authors, editors, and reviewers by drawing attention to sections of the manuscript that contain or should contain various rigor criteria and key resources. For details on the results shown here, including references cited, please follow this link.
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