The Female-Predominant Persistent Immune Dysregulation of the Post-COVID Syndrome
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Abstract
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SciScore for 10.1101/2021.05.25.21257820: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:This study had several limitations. First, the study design is a prospective cohort without strict inclusion criteria which allows for heterogeneity across the sample population. This was intentional as the GIM clinic is best suited for evaluating patients …
SciScore for 10.1101/2021.05.25.21257820: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:This study had several limitations. First, the study design is a prospective cohort without strict inclusion criteria which allows for heterogeneity across the sample population. This was intentional as the GIM clinic is best suited for evaluating patients with symptoms across multiple systems. Second, the selection of patients with multiple symptoms increased the concentration of patients with PoCoS, as patients with limited symptoms suggestive of one organ system involvement or those with already identified post COVID end organ damage were directly triaged to the appropriate specialty, e.g. anosmia to ENT, pulmonary fibrosis to Pulmonology. This was also intentional as we had designed a treatment program directed at helping these individuals. Third, our population was 94% White/Caucasian, and involved no patients of Hispanic descent. This was unintentional and likely secondary to our local demographic and differences in health seeking behaviors. Therefore, future research in a more diverse population is warranted. Fourth, the standard lab panel was not ordered in all patients, which reflects referring provider preference or patient-specific clinical decisions. Because of these limitations, our study data may not be widely generalizable to all PASC patients but provides previously unreported insights into PoCoS and its likely immune dysregulation etiology.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a protocol registration statement.
Results from scite Reference Check: We found no unreliable references.
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