Decreased serum levels of the inflammaging marker miR-146a are associated with clinical non-response to tocilizumab in COVID-19 patients

  1. Jacopo Sabbatinelli
  2. Angelica Giuliani
  3. Giulia Matacchione
  4. Silvia Latini
  5. Noemi Laprovitera
  6. Giovanni Pomponio
  7. Alessia Ferrarini
  8. Silvia Svegliati Baroni
  9. Marianna Pavani
  10. Marco Moretti
  11. Armando Gabrielli
  12. Antonio Domenico Procopio
  13. Manuela Ferracin
  14. Massimiliano Bonafè
  15. Fabiola Olivieri

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Abstract

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  1. Version published to 10.1016/j.mad.2020.111413
  2. Version published to 10.1101/2020.07.11.20151365v2 on medRxiv
  3. ScreenIT

    SciScore for 10.1101/2020.07.11.20151365: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementConsent: All enrolled subjects provided written informed consent.
    IRB: The study was approved by the Regional Institutional Review Board (Comitato Etico Regione Marche) and was conducted in accordance with the Declaration of Helsinki. A Simon’s optimal two-stage design was adopted.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    Statistical analysis was performed using SPSS version 26 (IBM, USA).
    SPSS
    suggested: (SPSS, RRID:SCR_002865)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: We found the following clinical trial numbers in your paper:

    IdentifierStatusTitle
    NCT04315480Active, not recruitingTocilizumab for SARS-CoV2 (COVID-19) Severe Pneumonitis

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  4. Version published to 10.1101/2020.07.11.20151365v1 on medRxiv