Risk and severity of SARS-CoV-2 reinfections during 2020–2022 in Vojvodina, Serbia: A population-level observational study
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SciScore for 10.1101/2022.04.08.22273571: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: Sample collection for laboratory diagnosis of COVID-19 formed part of the standard patient management, thus, only oral informed patient consent was required.
IRB: According to the law, no approval by the Ethics Committee for the retrospective analysis of anonymized data is required in Serbia.Sex as a biological variable not detected. Randomization Random selection was applied if several controls corresponded to a study case by using a random number generator. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources : StataCorp LLC. 2019) and TIBCO Statistica™ 14.0.0 (license for University of Novi Sad) were used for matching and … SciScore for 10.1101/2022.04.08.22273571: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: Sample collection for laboratory diagnosis of COVID-19 formed part of the standard patient management, thus, only oral informed patient consent was required.
IRB: According to the law, no approval by the Ethics Committee for the retrospective analysis of anonymized data is required in Serbia.Sex as a biological variable not detected. Randomization Random selection was applied if several controls corresponded to a study case by using a random number generator. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources : StataCorp LLC. 2019) and TIBCO Statistica™ 14.0.0 (license for University of Novi Sad) were used for matching and statistical analyses. StataCorpsuggested: (Stata, RRID:SCR_012763)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:We must emphasize some limitations. Both primary infections and reinfections were diagnosed mainly by Ag-RDT testing without subsequent confirmative RT-PCR testing of positive results. There is a lack of evidence of genotyping variance, threshold cycle values as well as at least one negative between two positive RT-PCR tests in patients with suspected reinfection.34 Therefore, the possibility that reinfection was caused by genetically different SARS-CoV-2 variants compared to primary infection could not be investigated. Most asymptomatic patients and those who did not seek testing were not captured, particularly in the early pandemic days. Also, if previously infected people were tested less due to their presumed natural immunity, the reinfection rate could have been underestimated. Given missed asymptomatic reinfections, the proportion of severe reinfections is certainly substantially over-estimated many-fold. Matching was not implemented to control for differences in race, nationality and education level that might influence the decision to be vaccinated or vaccine choice. Our study offers large-scale population-level evidence on reinfections over a two-year period. Since spatiotemporal differences are relevant to SARS-CoV-2 reinfections, longer prospective population-based studies with well characterized virologic and immunologic data are needed to assess the risk of reinfection in the future and whether low severity remains a key feature.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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