Post-vaccination infection rates and modification of COVID-19 symptoms in vaccinated UK school-aged children and adolescents: A prospective longitudinal cohort study
This article has been Reviewed by the following groups
Listed in
- Evaluated articles (ScreenIT)
Abstract
Article activity feed
-
-
SciScore for 10.1101/2022.03.13.22272176: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: Ethics approval was granted by the KCL Ethics Committee (LRS-19/20-18210).
Consent: Upon registration with the app, all participants were provided with study information, and gave consent for their data to be used for COVID-19 research.Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:However, we also acknowledge …
SciScore for 10.1101/2022.03.13.22272176: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: Ethics approval was granted by the KCL Ethics Committee (LRS-19/20-18210).
Consent: Upon registration with the app, all participants were provided with study information, and gave consent for their data to be used for COVID-19 research.Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:However, we also acknowledge the weaknesses of our study. Our data are generated by a volunteer citizen-science initiative delivered through an app, with the CSS cohort more likely to be of White Caucasian ethnicity and higher family socioeconomical status than the overall UK population 14. By virtue of UK government policy timing and age-tiered approach, our study was restricted to considering single-dose vaccination with BNT162b2 in CYP aged 12-17 years; our results may not apply to other vaccines or in younger age- groups. Our study was conducted with the prevailing SARS-CoV-2 variants Delta and Omicron; the impact of vaccination (both effectiveness and durability) and the profile of post-vaccination COVID-19 might differ with other variants. Indeed, the durability of vaccine protection against Omicron beyond 3 months in our cohort remains to be determined, due to insufficient data, noting here the ability to assess vaccination effectiveness in CYP naïve to SARS-CoV-2 is dwindling rapidly, given widespread infection in the community, particularly CYP. Vaccinated CYP were also much more likely to be tested for SARS-CoV-2 than unvaccinated CYP, for reasons that we are unable to determine. Our data do not allow determination of causal variants for CYP testing positive either post- or prior to vaccination: we can only infer likely variant based on population prevalences at time of testing. Vaccination can attenuate viral RNA shedding 29; this might result in the overestimation...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
-
