SARS-CoV-2 seroprevalence in a strictly-Orthodox Jewish community in the UK: A retrospective cohort study
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SciScore for 10.1101/2021.02.01.21250839: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Ethics: The study was approved by the London School of Hygiene & Tropical Medicine Ethics Committee (Ref 22532).
Consent: Verbal informed consent was given during the telephone survey and written consent provided prior to phlebotomy.Randomization We obtained a comprehensive list of all resident households within the community, held by our community collaborators, and randomly selected households for the study. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources We used cut-off values for the SARS-CoV-2 immunoassay from previous validation studies for antibodies against … SciScore for 10.1101/2021.02.01.21250839: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Ethics: The study was approved by the London School of Hygiene & Tropical Medicine Ethics Committee (Ref 22532).
Consent: Verbal informed consent was given during the telephone survey and written consent provided prior to phlebotomy.Randomization We obtained a comprehensive list of all resident households within the community, held by our community collaborators, and randomly selected households for the study. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources We used cut-off values for the SARS-CoV-2 immunoassay from previous validation studies for antibodies against trimeric-spike, nucleocapsid and receptor binding domain. antibodies against trimeric-spike, nucleocapsid and receptor binding domain.suggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our study has a number of limitations. We recruited 38% of households that were approached and obtained serum samples from 70% of study participants. This enrollment rate is similar to other national COVID-19 household surveillance studies, such as the ONS COVD-19 Infection survey27, suggesting it is unlikely to be a major source of bias. Individuals who gave serum samples were slightly older than those from whom serum was unavailable which may result in an over-estimation of the overall population seroprevalence. We relied on self-report of presumed COVID-19 illness which may be unreliable. However the timings of self reported illness match well to national surveillance data and self-reported illness was strongly associated with the presence of anti-spike antibodies suggesting that in this population this was a reliable metric. Although our study was conducted in a strictly Orthodox Jewish community, these communities share many characteristics with other ethnic and religious minority groups including larger family sizes, increased population density, children attending select schools, regular attendance at communal events and gatherings, and English as a second language. As such our findings are likely relevant to other tightly-knit ethnic and religious minority groups in the UK and elsewhere. Our work, conducted in direct collaboration with the community, should be a model for understanding risk in minority populations where there are no similar published data currently. I...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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