Evaluating social and spatial inequalities of large scale rapid lateral flow SARS-CoV-2 antigen testing in COVID-19 management: An observational study of Liverpool, UK (November 2020 to January 2021)

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Abstract

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  1. SciScore for 10.1101/2021.02.10.21251256: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    NIH rigor criteria are not applicable to paper type.

    Table 2: Resources

    No key resources detected.


    Results from OddPub: Thank you for sharing your code.


    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    There are strengths and weaknesses to our study. We use timely data covering all tests within Liverpool to promptly evaluate a key COVID-19 policy area with little prior evidence. Data were linked to novel geospatial information to contextualise patterns in uptake. Whilst the geospatial data were valuable, there were some discrepancies in data coverage and timing. Although neighbourhood characteristics tend to occur on longer-term trends rather than annual fluctuations [16], our analysis highlights the difficulty in the need for timely socio-economic data for making informed decisions. Our models are cross-sectional and association-based, limiting any causal interpretation. Observations are area based and thus susceptible to ecologic fallacy, which we have attempted to mitigate in our interpretations (also see Appendix E). Analyses are undertaken for small statistical zones that may not reflect actual neighbourhoods, and their defined shapes and sizes may influence the results. Our study shows that provision of free and voluntary asymptomatic community testing is affected by substantial social and spatial inequalities, typical of the ‘inverse care’ law but with a distinctive digital exclusion factor consistent with the digitally intensive means of accessing testing (participants are usually registered via smartphone and receive results by text message or email, with work-arounds for those without mobile phones). We found large relative inequalities by level of deprivation in ...

    Results from TrialIdentifier: No clinical trial numbers were referenced.


    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


    Results from JetFighter: We did not find any issues relating to colormaps.


    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

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