Influence of age on the effectiveness and duration of protection of Vaxzevria and CoronaVac vaccines: A population-based study
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SciScore for 10.1101/2021.08.21.21261501: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization Exposure and outcomes: We defined vaccination status for each vaccine based on the time elapsed since the administration of a vaccine dose: We defined the period up to 13 days after the first dose as the reference period for VE estimation based on results of a Phase III randomized controlled trial8 and three test-negative studies. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We …SciScore for 10.1101/2021.08.21.21261501: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization Exposure and outcomes: We defined vaccination status for each vaccine based on the time elapsed since the administration of a vaccine dose: We defined the period up to 13 days after the first dose as the reference period for VE estimation based on results of a Phase III randomized controlled trial8 and three test-negative studies. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:However, our study is also subject to some limitations. First, as VE was estimated using observational data, our analysis is subject to data availability and, therefore, to potential confounders. Although our analyses were not controled for comorbidities, crude and adjusted VE estimates were similar. In addition, comorbidities have been identified as the causal pathway between age and COVID-19 severity. Therefore, by controlling for age, we are also indirectly controlling for comorbidities.29 Second, in contrast to many VE studies, the reference period used herein for comparison purposes was 1-13 days after vaccination. Although using early post-vaccination as a reference may underestimate VE, previous studies have used a similar approach and obtained VE results similar to those found in clinical trials.30, 31 The early post-vaccination period can also be used as a bias indicator related to differences in SARS-CoV-2 infection risk. Additionally, the effectiveness results of the present report are similar, in the pertinent age ranges, to reports on both vaccines using distinct approaches.1, 19, 20 Finally, we also performed sensitivity analysis, which demonstrated similar results when a 0-10 day reference period was applied. Using the data available in Brazil, we estimated overall VE for each vaccine evaluated as well as by age group. Vaxzevria/Fiocruz and CoronaVac/Butantan were both shown to be highly protective against severe COVID-19 in the population aged up to 80 years, ...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- No funding statement was detected.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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