Model-based assessment of SARS-CoV-2 Delta variant transmission dynamics within partially vaccinated K-12 school populations
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Abstract
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Jinzhi Lei
Review 1 "Model-Based Assessment of SARS-CoV-2 Delta Variant Transmission Dynamics Within Partially Vaccinated K-12 School Populations"
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Strength of evidence
Reviewers: J Lei (Tiangong University) | 📗📗📗📗◻️
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SciScore for 10.1101/2021.08.20.21262389: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:This study has limitations. First, community contact rates measured in the survey may reflect underestimates of actual community contact rates, as vaccination prevalence has increased since February – April of 2021 and community contacts increased with vaccination prevalence (survey data). Thus, our estimates of excess cases attributable …
SciScore for 10.1101/2021.08.20.21262389: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:This study has limitations. First, community contact rates measured in the survey may reflect underestimates of actual community contact rates, as vaccination prevalence has increased since February – April of 2021 and community contacts increased with vaccination prevalence (survey data). Thus, our estimates of excess cases attributable to school transmission may be slight underestimates. Nevertheless, our previous work has shown that the effect of community transmission is minimized when within-school precautions are implemented [9]. Second, our transmission model does not capture all the precautions outlined in CDC guidance, including the effect of spacing desks three feet apart, or handwashing. Such precautions are difficult to model using a contact-based transmission model, and thus our estimates may overestimate risk if schools continue to emphasize such measures. Moreover, testing is an important component of the CDPH plan for return to in-person schooling. While we including testing as a potential NPI, we do not thoroughly investigate various testing routines that yield the optimal benefit, as does other work [54]. Third, most of our model simulations assume a high vaccine effectiveness against symptomatic COVID-19. Vaccine effectiveness may change as novel variants emerge and circulate; however, early studies indicate that vaccine effectiveness against variants of concern— including Delta—generally remain high [55]. Fourth, our initial conditions for seroprevalence i...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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