Efficacy and safety of hydroxychloroquine as pre-and post-exposure prophylaxis and treatment of COVID-19: A systematic review and meta-analysis of blinded, placebo-controlled, randomized clinical trials.

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1. Version published to 10.1016/j.lana.2021.100062

   Oct 1, 2021
2. 

   ScreenIT

   Jun 18, 2021

   SciScore for 10.1101/2021.06.12.21258831: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Ethics	not detected.
   Sex as a biological variable	not detected.
   Randomization	not detected.
   Blinding	13 The following domains were evaluated: sequence generation and allocation concealment (selection bias), blinding of participants and personnel (performance bias), blinding of outcome assessment (detection bias), incomplete outcome data (attrition bias), selective outcome reporting (reporting bias), sample size calculation, power analysis, and early stopping for futility (operational bias), outcome measurements (information bias), and the authors’ financial or non-financial conflicts of interest that could appear to affect the judgment of research team when designing, conducting, or reporting study.
   Powe…

   SciScore for 10.1101/2021.06.12.21258831: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Ethics	not detected.
   Sex as a biological variable	not detected.
   Randomization	not detected.
   Blinding	13 The following domains were evaluated: sequence generation and allocation concealment (selection bias), blinding of participants and personnel (performance bias), blinding of outcome assessment (detection bias), incomplete outcome data (attrition bias), selective outcome reporting (reporting bias), sample size calculation, power analysis, and early stopping for futility (operational bias), outcome measurements (information bias), and the authors’ financial or non-financial conflicts of interest that could appear to affect the judgment of research team when designing, conducting, or reporting study.
   Power Analysis	13 The following domains were evaluated: sequence generation and allocation concealment (selection bias), blinding of participants and personnel (performance bias), blinding of outcome assessment (detection bias), incomplete outcome data (attrition bias), selective outcome reporting (reporting bias), sample size calculation, power analysis, and early stopping for futility (operational bias), outcome measurements (information bias), and the authors’ financial or non-financial conflicts of interest that could appear to affect the judgment of research team when designing, conducting, or reporting study.
   Cell Line Authentication	Authentication: 13 The following domains were evaluated: sequence generation and allocation concealment (selection bias), blinding of participants and personnel (performance bias), blinding of outcome assessment (detection bias), incomplete outcome data (attrition bias), selective outcome reporting (reporting bias), sample size calculation, power analysis, and early stopping for futility (operational bias), outcome measurements (information bias), and the authors’ financial or non-financial conflicts of interest that could appear to affect the judgment of research team when designing, conducting, or reporting study.

   Table 2: Resources

   Software and Algorithms
   Sentences	Resources
   2.1 Search strategy: Searches for studies were performed in PubMed, Web of Science, Embase, Lilacs, the website ClinicalTrials.gov and the preprint server medRxiv from January 1, 2020 to May 17, 2021.	PubMed suggested: (PubMed, RRID:SCR_004846) Embase suggested: (EMBASE, RRID:SCR_001650)
   Analyses were conducted using Review Manager, version 5.3 (Cochrane IMS).	Review Manager suggested: None Cochrane IMS suggested: None

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   Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

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   Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:

   Out results had limitations and included trials with a high risk for operational bias. In addition, we found an important influence of non-peer reviewed studies in the quality of evidence for some outcomes of interest. However, the certainty of the results on the lack of clinical benefit for HCQ was rated as moderate and we believe that the true effect is probably close to the estimated effect. Finally, we lack in analyzing potential adverse events dose-response relationships in patients treated with HCQ.

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   Results from TrialIdentifier: No clinical trial numbers were referenced.

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   Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

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   Results from JetFighter: We did not find any issues relating to colormaps.

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   Results from rtransparent:

   • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
   • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
   • No protocol registration statement was detected.

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   Results from scite Reference Check: We found no unreliable references.

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3. 

   Version published to 10.1101/2021.06.12.21258831v1 on medRxiv

   Jun 15, 2021