Suboptimal antibody response against SARS-CoV-2 Omicron variant after third dose of mRNA vaccine in kidney transplant recipients

  1. Ayman Al Jurdi
  2. Rodrigo B. Gassen
  3. Thiago J. Borges
  4. Isadora T. Lape
  5. Leela Morena
  6. Orhan Efe
  7. Zhabiz Solhjou
  8. Rania El Fekih
  9. Christa Deban
  10. Brigid Bohan
  11. Vikram Pattanayak
  12. Camille N. Kotton
  13. Jamil R. Azzi
  14. Leonardo V. Riella

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Abstract

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  1. Version published to 10.1016/j.kint.2022.04.009
  2. ScreenIT

    SciScore for 10.1101/2022.01.03.22268649: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsIRB: Study approval: The study was approved by the institutional review board at Mass General Brigham (IRB 2021P000043).
    Consent: All subjects signed written informed consent forms prior to enrollment in the study.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    SPSS v24 (Chicago, IL) and GraphPad Prism v9.1.2 (San Diego, CA) were used for statistical analysis and creation of figures.
    SPSS
    suggested: (SPSS, RRID:SCR_002865)
    GraphPad Prism
    suggested: (GraphPad Prism, RRID:SCR_002798)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    It is worth noting that a limitation of the SVNT is that it is not able to measure neutralizing antibodies directed against non-RBD regions of the spike protein as it only measures RBD-ACE2 interactions. We were thus able to provide a detailed characterization of antibody responses to SARS-CoV-2 variants in KTRs, including the Omicron variant, and to evaluate the alloimmune safety of a third vaccine dose and found no evidence of allograft injury, de novo DSA development and no episodes of allograft rejection. This is consistent with what has been reported after two25–27 and three vaccine doses11,12,14 in solid organ transplant recipients. Our study has limitations, including its small sample size, observational design, lack of a control group of KTRs who did not receive a third vaccine dose, and lack of assessment of the cellular response to vaccination. Further studies evaluating the cellular response to the Omicron variant and the implications of the reduced neutralization ability with regards to risk and severity of infections in KTRs are needed. In summary, we found that a third dose of SARS-CoV-2 mRNA vaccination in KTRs was associated with an increased antiviral antibody response against WT and variants of SARS-CoV-2, and while the neutralizing responses to the Omicron variant increased in some, overall they remained markedly diminished. Strategies designed to improve antiviral immune responses to the Omicron and future variants, such as with additional homologous28 or ...

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a protocol registration statement.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2022.01.03.22268649 on medRxiv