Statistical Decision Properties of Imprecise Trials Assessing Coronavirus Disease 2019 (COVID-19) Drugs
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Abstract
No abstract available
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SciScore for 10.1101/2020.05.26.20114009: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your code.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:A limitation of this paper is that it only considers treatment choice using data from one trial. In practice, a clinician may learn the findings of multiple trials and may also be informed by observational data. The concept of near-optimality is well-defined in these more complex settings, but methods for practical application are yet …
SciScore for 10.1101/2020.05.26.20114009: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your code.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:A limitation of this paper is that it only considers treatment choice using data from one trial. In practice, a clinician may learn the findings of multiple trials and may also be informed by observational data. The concept of near-optimality is well-defined in these more complex settings, but methods for practical application are yet to be developed. A further issue beyond the scope of this paper concerns the dynamics of treatment choice when new trials and observational evidence may emerge in the future. The concept of near-optimality should be extendable to such settings. However, methodology for application is yet to be developed. Dynamic analysis of treatment choice made with hypothesis tests may be especially difficult to perform, because testing views standard care and new treatments asymmetrically. As new evidence accumulates over time, the consensus designation of standard care may change, leading to a change in the null hypothesis when new trials are evaluated. The implications for patient welfare are unclear.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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