No independent associations between physical activity and clinical outcomes among hospitalized patients with moderate to severe COVID-19
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SciScore for 10.1101/2020.11.25.20237925: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The study was approved by the Ethics Committee of Clinical Hospital of the School of Medicine of the University of Sao Paulo and by the Ethics Committee of Ibirapuera Field Hospital.
Consent: The participants provided written informed consent before being enrolled in the study (approval number: 30959620.4.0000.0068).Randomization Study design: This is a prospective, cohort study nested within a multicenter, randomized controlled trial designed to test the safety and efficacy of vitamin D3 supplementation in hospitalized patients with severe COVID-19 (ClinicalTrials.gov Identifier: NCT04449718), conducted between June 2, 2020 and October 7, 2020. Blinding not … SciScore for 10.1101/2020.11.25.20237925: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The study was approved by the Ethics Committee of Clinical Hospital of the School of Medicine of the University of Sao Paulo and by the Ethics Committee of Ibirapuera Field Hospital.
Consent: The participants provided written informed consent before being enrolled in the study (approval number: 30959620.4.0000.0068).Randomization Study design: This is a prospective, cohort study nested within a multicenter, randomized controlled trial designed to test the safety and efficacy of vitamin D3 supplementation in hospitalized patients with severe COVID-19 (ClinicalTrials.gov Identifier: NCT04449718), conducted between June 2, 2020 and October 7, 2020. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:The main limitations of this study involve its observational nature, which hampers causative relationships; the small sample size, which increases the chances of type 2 errors, particularly considering the low incidence for the secondary outcomes; the use of a questionnaire to assess physical activity, which is prone to recall bias, overreporting, and limited time frame of evaluation (i.e., 1 year); and the lack of patients’ follow-up after the hospital discharge. In conclusion, among hospitalized patients with COVID-19, physical activity did not associate with hospital length of stay or any other clinically relevant outcomes. These findings, which needs further replication in larger cohorts, suggest that previous physical activity levels may not change the prognosis of severe COVID-19.
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04449718 Completed Vitamin D Supplementation in Patients With COVID-19 Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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