Changes in mental health symptoms from pre-COVID-19 to COVID-19 among participants with systemic sclerosis from four countries: A Scleroderma Patient-centered Intervention Network (SPIN) Cohort study

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Abstract

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  1. SciScore for 10.1101/2020.06.13.20128694: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementConsent: SPIN Cohort participants provide informed consent for cohort participation and for contact about additional SPIN studies.
    IRB: The SPIN (#MP-05-2013-150) and SPIN COVID-19 (#2021-2286) Cohorts were approved by the Research Ethics Committee of the Centre intégré universitaire de santé et de services sociaux du Centre-Ouest-de-l’Île-de-Montréal.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variableVariables entered in models included male sex (reference female), age (continuous), non-White race or ethnicity (reference White), education years (continuous), living alone (reference living with others), country (reference France), working part- or full-time (reference not working), time since SSc diagnosis (continuous), diffuse subtype (reference limited or sine scleroderma), interstitial lung disease presence, interference from breathing problems (continuous), overweight or obese (reference normal body mass index or less), overlap syndrome presence, PROMIS Physical Function 4a v1.0 (continuous)

    Table 2: Resources

    No key resources detected.


    Results from OddPub: Thank you for sharing your data.


    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    There are limitations to consider. First, the SPIN Cohort is a convenience sample, although participant characteristics are similar to other large SSc cohorts.8 Second, participants complete questionnaires online, which may reduce generalizability. Third, it was not possible to capture and include local variables, such as the degree participants’ communities were affected or whether public health interventions were consistently followed in those communities. Nonetheless, data were collected at a time when social isolations were generally at their most conservative. Finally, different MCID values may be chosen. The 4-point MCID we used for anxiety symptoms was conservative; others have recommended MCIDs of 2 to 3 points,30 and it is possible that we may have underestimated the degree of patient-important change. In sum, this was the first study to compare mental health symptoms prior to and during the COVID-19 outbreak. We found that anxiety symptoms increased substantially and that the magnitude was associated with country; increases were highest in the United States and United Kingdom and more moderate in France and Canada. There were minimal differences in depressive symptoms during COVID-19 compared to pre-COVID-19. An important finding was that people who received mental health care prior to COVID-19 experienced substantially smaller anxiety symptom increases than other participants. These findings, which differ from early reports of results from younger adults, underline...

    Results from TrialIdentifier: No clinical trial numbers were referenced.


    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


    Results from JetFighter: We did not find any issues relating to colormaps.


    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

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