A prospective study of long-term outcomes among hospitalized COVID-19 patients with and without neurological complications
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SciScore for 10.1101/2021.03.18.21253881: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement Consent: Inclusion criteria were: age ≥18 years, hospital admission, reverse-transcriptase-polymerase-chain-reaction (RT-PCR) positive SARS-CoV-2 infection from nasopharyngeal sampling, survival to discharge and consent to participate in a follow-up interview.
IRB: Standard Protocol Approvals and Patient Consents: This study was approved by the NYU Grossman School of Medicine Institutional Review Board.Randomization Controls were propensity score matched 1:1 to cases by age, gender and intubation status (as a marker of illness severity during index hospitalization) using a matching ratio of 0.01, random order drawing of matches, without replacement and with … SciScore for 10.1101/2021.03.18.21253881: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement Consent: Inclusion criteria were: age ≥18 years, hospital admission, reverse-transcriptase-polymerase-chain-reaction (RT-PCR) positive SARS-CoV-2 infection from nasopharyngeal sampling, survival to discharge and consent to participate in a follow-up interview.
IRB: Standard Protocol Approvals and Patient Consents: This study was approved by the NYU Grossman School of Medicine Institutional Review Board.Randomization Controls were propensity score matched 1:1 to cases by age, gender and intubation status (as a marker of illness severity during index hospitalization) using a matching ratio of 0.01, random order drawing of matches, without replacement and with priority given to exact matches. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources All analyses were conducted using IBM SPSS Statistics for Mac version 26 (IBM Corp., Armonk, NY). SPSSsuggested: (SPSS, RRID:SCR_002865)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:There are limitations to our work. First, though all patients completed the mRS evaluation, the sickest patients were unable to complete other metrics due to limited function. Thus, secondary outcomes may actually be worse than what we were able to measure. Additionally, family members of patients who did poorly may be less motivated to participate in research. Second, certain outcomes may be confounded by unmeasured factors. For example, return to work may be impacted by the current economic environment. Anxiety, depression, fatigue and sleep may be similarly impacted by unmeasured societal, economic and environmental pandemic-associated factors. Comparing COVID-19 patients to similar community members without COVID-19 would help quantify the impact of some of these unmeasured factors. Third, though we identified high rates of disability among both neurological COVID-19 patients and controls, this study was not designed to determine whether the deficits measured by these metrics are static or represent ongoing injury as suggested by some “long-hauler” and post-COVID literature39. Since cognitive impairment and mood abnormalities occur in over 50% of ARDS survivors40, it is possible that the level of disability we are documenting is not specific to SARS-CoV-2, but rather a result of factors related to critical viral illness. Additional one-year follow-up in this cohort may help clarify the trajectory of recovery. Fourth, the telephone MOCA is meant to screen for cognitive imp...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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