N-Terminal Finger Stabilizes the S1 Pocket for the Reversible Feline Drug GC376 in the SARS-CoV-2 Mpro Dimer
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SciScore for 10.1101/2021.02.16.431021: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
Software and Algorithms Sentences Resources Kinetic data corresponding the interaction of SARS-CoV Mpro and SARS CoV-2 Mpro with GC376 compound were analyzed using computer-fit calculation (Prism 4.0, GraphPad Software). Prismsuggested: (PRISM, RRID:SCR_005375)GraphPadsuggested: (GraphPad Prism, RRID:SCR_002798)All three structures were determined by molecular replacement with the crystal structure of the free enzyme of the SARS-CoV-2 Mpro (PDB entry 6Y7M as search model, using the Phaser program from Phenix[49], version v1.18.1-3855). Phasersuggested: (Phaser, RRID:SCR_014219)Refinement of all the structures was performed with … SciScore for 10.1101/2021.02.16.431021: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
Software and Algorithms Sentences Resources Kinetic data corresponding the interaction of SARS-CoV Mpro and SARS CoV-2 Mpro with GC376 compound were analyzed using computer-fit calculation (Prism 4.0, GraphPad Software). Prismsuggested: (PRISM, RRID:SCR_005375)GraphPadsuggested: (GraphPad Prism, RRID:SCR_002798)All three structures were determined by molecular replacement with the crystal structure of the free enzyme of the SARS-CoV-2 Mpro (PDB entry 6Y7M as search model, using the Phaser program from Phenix[49], version v1.18.1-3855). Phasersuggested: (Phaser, RRID:SCR_014219)Refinement of all the structures was performed with phenix.refine in Phenix software. Phenixsuggested: (Phenix, RRID:SCR_014224)Final models displayed using PyMOL molecular graphics software (Version 2.0 Schrödinger, LLC). PyMOLsuggested: (PyMOL, RRID:SCR_000305)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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