Panbio™ rapid antigen test for SARS-CoV-2 has acceptable accuracy in symptomatic patients in primary health care
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SciScore for 10.1101/2020.11.13.20231316: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement Consent: All potentially eligible participants were asked to sign an informed consent document and to answer a short questionnaire that asked about the reasons for RT-PCR testing (referral by a GP due to symptoms, close contact, others); socio-demographic information (sex and age); and the presence of symptoms, type of symptoms, and number of days since symptom onset or close contact to a positive SAR-CoV-2 patient.
IRB: Ethics and funding: This study was conducted following the Declaration of Helsinki and was approved by the Balearic Research Ethics Committee (IB 4350/20 PI on 30/09/2020) and by the Mallorca Primary Care Research Commission.Randomization not … SciScore for 10.1101/2020.11.13.20231316: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement Consent: All potentially eligible participants were asked to sign an informed consent document and to answer a short questionnaire that asked about the reasons for RT-PCR testing (referral by a GP due to symptoms, close contact, others); socio-demographic information (sex and age); and the presence of symptoms, type of symptoms, and number of days since symptom onset or close contact to a positive SAR-CoV-2 patient.
IRB: Ethics and funding: This study was conducted following the Declaration of Helsinki and was approved by the Balearic Research Ethics Committee (IB 4350/20 PI on 30/09/2020) and by the Mallorca Primary Care Research Commission.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources All statistical calculations were performed using Stata 13 (StataCorp, College Station, TX, USA) with the Stata DIAGT module. StataCorpsuggested: (Stata, RRID:SCR_012763)Results from OddPub: Thank you for sharing your data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Strengths and limitations: The present study is the largest evaluation of the Panbio Ag-RDT in samples from symptomatic and asymptomatic patients in real-world context. This is a strength of our study because this is the setting where the majority of the patients with mild symptoms (up to 75%)(12) and close contacts are visited and followed-up. We incorporated COVID-19 testing into the usual care and management of patients with suspected SARS-CoV-2 infection and less than 2% of participants denied taking part in the study. Our study has several limitations. We only assessed one type of Ag-RDT that targeted the SARS-CoV-2 N (nucleocapsid) protein, although other tests are available. Also, we only examined two types of testing scenarios —referral by a GP based on symptoms and close contact with a confirmed case — and therefore cannot make inferences about the applicability of this test in other scenarios (screening of nursing-homes, workplaces, etc.). Additional rigorous studies are needed to establish the optimal performance characteristics for Ag-RDTs that have different protein targets, are employed in different specific settings, and that have different pretest probabilities. There is no standardized method to establishing the infectiousness of a patient with confirmed SARS-CoV-2 based on viral load. Ct values can vary among studies according to the type of test and target gene. We considered low viral load as a Ct value above 30 in patients with positive RT-PCR results (13...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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