High-risk exposure without personal protective equipment and infection with SARS-CoV-2 in-hospital workers - The CoV-CONTACT cohort
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SciScore for 10.1101/2020.09.17.20194860: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Ethics and regulatory issues: The study was approved by the French National Data Protection Commission (approval #920102), and the French Ethics committee (CPP-lle-de-France-6, #2020-A00280-39) and was registered on the Clinicaltrial.gov registry (NCT04259892).
Consent: All subjects provided written informed consent.Randomization not detected. Blinding Virology: The SARS-CoV-2 RT-PCR was performed blinded to contact characteristics and reported symptoms (see Supplementary appendix). Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources A serum was considered as positive for SARS-CoV-2 antibodies when … SciScore for 10.1101/2020.09.17.20194860: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Ethics and regulatory issues: The study was approved by the French National Data Protection Commission (approval #920102), and the French Ethics committee (CPP-lle-de-France-6, #2020-A00280-39) and was registered on the Clinicaltrial.gov registry (NCT04259892).
Consent: All subjects provided written informed consent.Randomization not detected. Blinding Virology: The SARS-CoV-2 RT-PCR was performed blinded to contact characteristics and reported symptoms (see Supplementary appendix). Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources A serum was considered as positive for SARS-CoV-2 antibodies when the signal exceeded the threshold set at 13,402 relative light units per second (RLU/s) for LuLISA or a 1.1 ratio for EurolMMUN. SARS-CoV-2suggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:A major limitation of our study is the absence of whole genome sequencing comparing the virus of the index subject and SARS-CoV-2-infected HCW. Therefore, the network of exposures and infection only suggests that the infection in a subject is the consequence of a high-risk exposure. However, sequencing would be restricted to RT-PCR positive subjects, which only represent 40% (26/65) of our population of confirmed and possible infections. Another limitation was that the type of contacts observed in the study has been modified by universal masking implemented on March, 18th, 2020. After this date, most at risk contacts were between two HCWs, which were less likely, but not unlikely, to result in SARS-CoV-2 transmission. All together, the rate of transmission observed in HCWs after high-risk exposure, which could be as large as 44%, and close to a recent report [25], strengthens the conclusion that universal masking of HCW, both during contacts with patients and colleagues, and at all times, is essential to prevent HCWs infection and maintain hospital capacities during outbreaks [26].
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04259892 Recruiting Viral Excretion in Contact Subjects at High/Moderate Risk of… NCT04259892 Recruiting Viral Excretion in Contact Subjects at High/Moderate Risk of… Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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