Mendelian randomization analysis identified genes pleiotropically associated with the risk and prognosis of COVID-19
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SciScore for 10.1101/2020.09.02.20187179: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our study has some limitations. The GWAS analyses did not control confounding factors which might affect the outcome. It is also unclear whether selection of the subjects in the GWAS studies was a representative of the …
SciScore for 10.1101/2020.09.02.20187179: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our study has some limitations. The GWAS analyses did not control confounding factors which might affect the outcome. It is also unclear whether selection of the subjects in the GWAS studies was a representative of the exposure-outcome distributions in the overall population, and therefore, the possibility of selection bias, which can affect estimation accuracy, could not be ruled out. The GWAS studies only examined the short-term effect of COVID-19 due to the limited duration of the COVID-19 pandemic, and we were unable to assess the long-term outcomes/lingering effects of COVID-19. Similarly, we could not analyze the genetic contribution of other interesting phenotypes, such as different disease behaviors among children/teens, adults and the elderly patients, and asymptomatic COVID-19, due to a lack of the corresponding GWAS summarized data. We only performed analyses using blood and lung eQTL data, more studies are needed to explore tissue-and cell-type-specific genes involved in the host responses to COVID-19 infection. Due to a lack of individual eQTL data, we could not quantify the changes in gene expression in patients with COVID-19 in comparison with the control.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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