Safety and immunogenicity of the COVID-19 vaccine BNT162b2 in patients undergoing chemotherapy for solid cancer

  1. Yohei Funakoshi
  2. Kimikazu Yakushijin
  3. Goh Ohji
  4. Wataru Hojo
  5. Hironori Sakai
  6. Ryo Takai
  7. Taku Nose
  8. Shinya Ohata
  9. Yoshiaki Nagatani
  10. Taiji Koyama
  11. Akihito Kitao
  12. Meiko Nishimura
  13. Yoshinori Imamura
  14. Naomi Kiyota
  15. Kenichi Harada
  16. Yugo Tanaka
  17. Yasuko Mori
  18. Hironobu Minami

Reviewed by

Read the full article

Listed in

Log in to save this article

Abstract

No abstract available

Article activity feed

  1. Version published to 10.1016/j.jiac.2021.12.021
  2. ScreenIT

    SciScore for 10.1101/2021.10.25.21265324: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsIRB: The study was approved by the Kobe University Hospital Ethics Committee (No. B2056714) and was conducted in accordance with the Declaration of Helsinki.
    Consent: All patients provided written informed consent for this study.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Antibodies
    SentencesResources
    Antibody titers against S1 were measured using the QuaResearch COVID-19 Human IgM IgG ELISA kit (Spike Protein-S1) (Cellspect, Inc., RCOEL961S1, Iwate, Japan).
    S1
    suggested: None
    Measurement of inflammatory cytokines: Serum inflammatory cytokines (Interferon [IL]-2, IL-4, IL-6, IL-8, IL-10, tumor necrosis factor [TNF] -α, interferon gamma [IFN]-γ, and granulocyte macrophage-colony stimulating factor [GM-CSF]) were probed using Bio Plex Pro Human Cytokine plex Panel (Bio-Rad, CA, USA) multiplex magnetic bead-based antibody detection kits following the manufacturer’s instructions.
    IL-4,
    suggested: None
    IL-4
    suggested: None
    IL-6
    suggested: None
    IL-8
    suggested: None
    IL-10
    suggested: None
    Software and Algorithms
    SentencesResources
    Standard curves for each analyte were generated using standards provided by the manufacturer and the collected data were analyzed using Bio-Plex Manager™ Software version 6.1 (Bio-Rad).
    Bio-Plex
    suggested: None
    Manager™
    suggested: (?Manager, RRID:SCR_016865)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2021.10.25.21265324v1 on medRxiv