Abnormal liver tests in patients with SARS-CoV-2 or influenza – prognostic similarities and temporal disparities
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SciScore for 10.1101/2020.10.23.20218230: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Local Institutional Review Board (#RMC-20-0142) approved the study that was performed according to Helsinki declaration. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Statistical analysis: We used SAS version 9.4 and PRISM 8 softwares. PRISMsuggested: (PRISM, RRID:SCR_005375)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in …SciScore for 10.1101/2020.10.23.20218230: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Local Institutional Review Board (#RMC-20-0142) approved the study that was performed according to Helsinki declaration. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Statistical analysis: We used SAS version 9.4 and PRISM 8 softwares. PRISMsuggested: (PRISM, RRID:SCR_005375)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Although this study includes a relatively large number of patients with an ample of clinical and laboratory data, it also has several limitations: First, it is retrospective and not all patients were systematically tested for liver enzymes and we had no control on the timing by which these tests were taken for each patient. Second, we had no access to laboratory results prior to hospitalization and could not accurately assess whether the observed abnormal liver tests during hospitalization is entirely new. We partially overcome this pitfall, by showing that the peak in abnormal liver tests is significantly higher than the nadir during hospitalization, suggesting that at least in the majority of patients, the maximal abnormal liver tests values are related to the acute disease and not to an underlying liver problem. Third, the cutoff value of 40IU/L for a definition of elevated GPT, GOT and GGT levels is largely arbitrary and was not adjusted for age, weight and gender. However, these cutoffs were used in previous studies(24), and by and large represent values in the range observed in 95% of the healthy population. In addition, the reason that we have not included the ALKP values in our primary analysis is that this enzyme is not necessarily liver-specific. In summary, in this study we show that abnormal liver tests are quite common and appear with similar frequency among hospitalized patients with either influenza, RSV or SARS-Cov-2 infections, although the timing of abnormal...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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