Gut microbiota, inflammation, and molecular signatures of host response to infection
This article has been Reviewed by the following groups
Listed in
- Evaluated articles (ScreenIT)
Abstract
No abstract available
Article activity feed
-
-
SciScore for 10.1101/2020.04.22.20076091: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Amino acid insufficiency will cause depletion of available aminoacylated tRNA, which is essential for the host to sense amino acid limitation and immune response (Brown et al., 2016, 2010; Harding et al., 2003). A recent study on several mammalian cell models reported that when aminoacyl-tRNA synthetase was inhibited, the cytokine …
SciScore for 10.1101/2020.04.22.20076091: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Amino acid insufficiency will cause depletion of available aminoacylated tRNA, which is essential for the host to sense amino acid limitation and immune response (Brown et al., 2016, 2010; Harding et al., 2003). A recent study on several mammalian cell models reported that when aminoacyl-tRNA synthetase was inhibited, the cytokine stimulated proinflammatory response would be substantially suppressed, and a single amino acid depletion, such as arginine or histidine, could also suppress the cytokine induced immune response (Kim et al., 2020). Thus the identified pathways regulating in aminoacyl-tRNA biosynthesis and arginine biosynthesis may be both involved in the inflammatory response. Additionally, arginine and BCAAs (i.e., valine, leucine and isoleucine), were also reported regulating innate and adaptive immune responses and enhancing intestinal development (Zhang et al., 2017). Collectively, these key roles that amino acids play in the immunoregulation may help explain how the PRS-related core OTUs modulate host inflammation via amino acid metabolism. Furthermore, given the high expression of ACE2 in the ileum and colon, and the role of ACE2 as a key regulator of dietary amino acid homeostasis and innate immunity (Hashimoto et al., 2012; Zhang et al., 2020), ACE2 may be another key mediator between gut microbiota and host inflammation. However, whether and how ACE2 may mediate the association between gut microbiota and COVID-19 severity warrants further mechanistic study. ...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
-
