Immunologic response, Efficacy, and Safety of Vaccines against COVID-19 Infection in Healthy and immunosuppressed Children and Adolescents Aged 2 – 21 years old: A Systematic Review and Meta-analysis

  1. Sara Sadeghi
  2. Yasamin Kalantari
  3. Sima Shokri
  4. Morteza Fallahpour
  5. Nahid Nafissi
  6. Azadeh Goodarzi
  7. Rohollah Valizadeh

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Abstract

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  1. Version published to 10.1016/j.jcv.2022.105196
  2. ScreenIT

    SciScore for 10.1101/2022.01.11.22269113: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Ethicsnot detected.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    Search Strategy: A systematic search was performed on databases including Ovid Medline, Cochrane Library, Scopus, Web of Sciences, Embase, Google Scholar, and ClinicalTrials.gov website until December 7th, 2021.
    Cochrane Library
    suggested: (Cochrane Library, RRID:SCR_013000)
    Embase
    suggested: (EMBASE, RRID:SCR_001650)
    Google Scholar
    suggested: (Google Scholar, RRID:SCR_008878)
    The combination of employed keywords and MeSH terms is attached in the supplementary data (Table S1).
    MeSH
    suggested: (MeSH, RRID:SCR_004750)
    Literature Screening: For the entire screening process, EndNote software, version 20, was utilized.
    EndNote
    suggested: (EndNote, RRID:SCR_014001)
    Data Analysis: We systematically reviewed and described all the information about immunogenicity, efficacy, and safety of all available vaccines for healthy children and adolescents or those with underlying diseases in Microsoft Word software, version 16.56.
    Microsoft Word
    suggested: None

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: We found the following clinical trial numbers in your paper:

    IdentifierStatusTitle
    NCT04918797RecruitingCOVAXIN in a Pediatric Cohort
    NCT04796896RecruitingA Study to Evaluate Safety and Effectiveness of mRNA-1273 CO…

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2022.01.11.22269113v1 on medRxiv