SARS-CoV-2 sample-to-answer nucleic acid testing in a tertiary care emergency department: evaluation and utility
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SciScore for 10.1101/2020.07.03.20145383: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Statistical analysis was performed using SPSS/PASW statistical program package, version 25 (IBM SPSS Inc., Chicago, IL, USA). SPSSsuggested: (SPSS, RRID:SCR_002865)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:As a response to the current need for extensive …
SciScore for 10.1101/2020.07.03.20145383: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Statistical analysis was performed using SPSS/PASW statistical program package, version 25 (IBM SPSS Inc., Chicago, IL, USA). SPSSsuggested: (SPSS, RRID:SCR_002865)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:As a response to the current need for extensive SARS-CoV-2 testing, several commercial nucleic acid detections assays have become available, all of which have their advantages and limitations. In the present study, the Novodiag® Covid-19 with reasonable sensitivity and high specificity in the analytical evaluation was made available for rapid SARS-CoV2 testing for four emergency departments. Timely results are required to facilitate efficient patient flow and effective patient cohorting. Subclinical COVID-19 infections do occur (16) and could potentially lead to spread of the disease in hospital settings. Prompt diagnosis is of especially high priority for patients admitted to the hospital through the emergency departments and therefore the possibility for rapid SARS-CoV-2 testing was first offered to these settings. Indeed, implementation of the Novodiag® provided results nearly 8 hours faster as compared to the large-scale PCR tests. A limitation of the present study is the use of three different large-scale PCR tests for reference, as analysis of all samples on one platform was not possible due to the global shortage in testing supplies at the time of the study and a heavy load of samples to be tested. As a limitation, it should also be noted that age distribution and clinical information was available only for the samples of the clinical evaluation. In conclusion, the Xpert® Xpress SARS-CoV-2 showed high sensitivity and specificity, and a reasonable sensitivity and high s...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a protocol registration statement.
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