Profiling COVID-19 pneumonia progressing into the cytokine storm syndrome: Results from a single Italian Centre study on tocilizumab versus standard of care
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SciScore for 10.1101/2020.05.01.20078360: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement Consent: Oral or written consent was obtained from patients.
IRB: The study was conducted in accordance with the ethical principles of the Helsinki Declaration and ethical approval was given by local Ethics Committee (CEUR-2020-Os-102).Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources All statistical analyses were performed using SPSS version 15.0 software (SPSS Inc). SPSSsuggested: (SPSS, RRID:SCR_002865)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when …
SciScore for 10.1101/2020.05.01.20078360: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement Consent: Oral or written consent was obtained from patients.
IRB: The study was conducted in accordance with the ethical principles of the Helsinki Declaration and ethical approval was given by local Ethics Committee (CEUR-2020-Os-102).Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources All statistical analyses were performed using SPSS version 15.0 software (SPSS Inc). SPSSsuggested: (SPSS, RRID:SCR_002865)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:This study has several limitations. It is a retrospective study, with some missing data due to the emergency context in which it has been realized. No conclusions on the efficacy and safety of treatment approach employed can be provided. Six patients were transferred from other hospitals so original baseline values from the first admission were unavailable. About 50% of the TOCI group were admitted to the ICU within 24 hours from admission, thus they already presented a more serious disease at the time of admission. The follow-up was limited from our hospital admission to discharge. Finally, measurement of viral load was not available. Nevertheless, the cohort is monocentric and it showed similar characteristics to those reported by Wang et al. [2], thus supporting the results, though preliminary. To conclude, our study showed that TOCI treated patients COVID-19 pneumonia were at the highest risk of cytokine storm [32]. Tocilizumab use prior to ventilation in ICU may be optimal since 50% of such cases died, remain ventilated and show serious superinfection. Whether the use of tocilizumab prior to ventilation will be vindicated in randomized trials is of major interest. Our findings also showed that cases receiving tocilizumab on ventilation generally had higher levels of inflammation than non-ventilated TOCI treated subjects, possibly suggesting that the latter group has an intrinsically milder disease with a better prognosis. Timing of anti-cytokine therapy is a key issue.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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SciScore for 10.1101/2020.05.01.20078360: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement Oral or written consent was obtained from patients. Randomization Despite the confounding factors, this suggests that therapy time in anti-cytokine randomized trials will be key. Blinding not detected. Power Analysis not detected. Sex as a biological variable Patients were predominantly male (77/111, 69.4%) with a mean age of 58.5±13.6 years. Table 2: Resources
Software and Algorithms Sentences Resources All statistical analyses were performed using SPSS version 15.0 software (SPSS Inc). SPSSsuggested: (SPSS, SCR_002865)Results from OddPub: We did not find a statement about open data. We also did …
SciScore for 10.1101/2020.05.01.20078360: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement Oral or written consent was obtained from patients. Randomization Despite the confounding factors, this suggests that therapy time in anti-cytokine randomized trials will be key. Blinding not detected. Power Analysis not detected. Sex as a biological variable Patients were predominantly male (77/111, 69.4%) with a mean age of 58.5±13.6 years. Table 2: Resources
Software and Algorithms Sentences Resources All statistical analyses were performed using SPSS version 15.0 software (SPSS Inc). SPSSsuggested: (SPSS, SCR_002865)Results from OddPub: We did not find a statement about open data. We also did not find a statement about open code. Researchers are encouraged to share open data when possible (see Nature blog).
About SciScore
SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore is not a substitute for expert review. SciScore checks for the presence and correctness of RRIDs (research resource identifiers) in the manuscript, and detects sentences that appear to be missing RRIDs. SciScore also checks to make sure that rigor criteria are addressed by authors. It does this by detecting sentences that discuss criteria such as blinding or power analysis. SciScore does not guarantee that the rigor criteria that it detects are appropriate for the particular study. Instead it assists authors, editors, and reviewers by drawing attention to sections of the manuscript that contain or should contain various rigor criteria and key resources. For details on the results shown here, including references cited, please follow this link.
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