Outcome of Conservative Therapy in Coronavirus disease-2019 Patients Presenting With Gastrointestinal Bleeding

  1. Shalimar
  2. Manas Vaishnav
  3. Anshuman Elhence
  4. Ramesh Kumar
  5. Srikant Mohta
  6. Chandan Palle
  7. Peeyush Kumar
  8. Mukesh Ranjan
  9. Tanmay Vajpai
  10. Shubham Prasad
  11. Jatin Yegurla
  12. Anugrah Dhooria
  13. Vikas Banyal
  14. Samagra Agarwal
  15. Rajat Bansal
  16. Sulagna Bhattacharjee
  17. Richa Aggarwal
  18. Kapil D. Soni
  19. Swetha Rudravaram
  20. Ashutosh K. Singh
  21. Irfan Altaf
  22. Avinash Choudekar
  23. Soumya J. Mahapatra
  24. Deepak Gunjan
  25. Saurabh Kedia
  26. Govind Makharia
  27. Anjan Trikha
  28. Pramod Garg
  29. Anoop Saraya

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Abstract

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  1. Version published to 10.1016/j.jceh.2020.09.007
  2. ScreenIT

    SciScore for 10.1101/2020.08.06.20169813: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementConsent: Ethical clearance: In this retrospective study, the requirement of consent was waived off, and ethical approval was obtained from the Institutional Ethics Committee, All India Institute of Medical Sciences, India (Ref No: IEC-253/17.04.2020).
    IACUC: Ethical clearance: In this retrospective study, the requirement of consent was waived off, and ethical approval was obtained from the Institutional Ethics Committee, All India Institute of Medical Sciences, India (Ref No: IEC-253/17.04.2020).
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    Data were analyzed using IBM SPSS statistical software (Version 20.0, Chicago, IL, USA).
    SPSS
    suggested: (SPSS, RRID:SCR_002865)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    Our study has a few limitations. Small sample size, single-centre retrospective design with predominantly descriptive nature of the study are its inherent limitations. In the absence of endoscopy, we were not sure of the exact cause of UGI bleeding in all patients. We presumed all patients with cirrhosis to have portal hypertension-related bleeding. It is well known that up to 25% of patients with cirrhosis may have a non-variceal cause of bleeding. The inclusion of patients predominantly with CLD limits generalizability to other causes of bleed. We had only one patient with a LGI bleed. In conclusion, conservative management strategies including pharmacotherapy, restrictive transfusion strategy, and close hemodynamic monitoring can successfully manage GI bleeding in COVID-19 patients and reduce the need for urgent endoscopy. The decision for proceeding with endoscopy should be taken by a multidisciplinary team after consideration of the patient’s condition, response to treatment, resources and the risks involved, on a case to case basis.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a protocol registration statement.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2020.08.06.20169813v2 on medRxiv
  4. Version published to 10.1101/2020.08.06.20169813v1 on medRxiv